ADA
-
Official Full Name
adenosine deaminase -
Overview
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been;described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe;combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired;cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been;associated with congenital hemolytic anemia. -
Synonyms
ADA;adenosine deaminase;adenosine aminohydrolase
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Zebrafish
- Bovine
- Insect Cell
- E.coli
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Bovine Intestine
- His
- Non
- Fc
- GST
- His&Fc&Avi
Involved Pathway
ADA involved in several pathways and played different roles in them. We selected most pathways ADA participated on our site, such as C-MYB transcription factor network,Metabolic pathways,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine salvage | TM9SF1,DGUOK,PNP5B,ADK,DCK,ADAL |
| Primary immunodeficiency | CD3E; CD3D,TNFRSF13C |
| Metabolism of nucleotides | UPP2,DTYMK,DPYDA.1,NUDT15,ADSS,PNP5B,PAICS,DCK,ADAL,DPYS |
| Metabolic pathways | ACSM4,LASS5,AKR1C3,POLR2K,IMPAD1,ALDH9A1A.1,TPH2,HYKK,COQ7,LIAS |
| C-MYB transcription factor network | CBX4,CEBPB,COL1A2,MYB,SMARCA2,CSF1R,MYC,TRIM28,CREBBP,LECT2 |
| Purine metabolism | PRPS1A,PNP,GUCY2E,ZNRD1,NME2B.1,NME2B.2,AMPD2,ENTPD5,IMPDH1B,NT5C2A |
| Metabolism | FAM36A,CRYM,PTPMT1,ACOT2,PDP2,FABP1B.1,NUDT11,DUT,CYP2Y3,UST |
Protein Function
ADA has several biochemical functions, for example, adenosine deaminase activity,protein binding,purine nucleoside binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADA itself. We selected most functions ADA had, and list some proteins which have the same functions with ADA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| adenosine deaminase activity | ADARB1A,ADARB2,ADAD2,CECR1A,ADAL,CECR1,ADARB1,ADAD1 |
| purine nucleoside binding | C6orf130,ADORA1 |
| zinc ion binding | RNF180,HNF4G,ZNF385D,PCGF5B,RFPL2,CSRP3,TRIM35-30,CHURC1,CPM,MYLIPB |
| protein binding | MAPK11,EIF4EBP3L,ITSN1,PLEKHA2,SPSB3,GPX7,NPRL2,NHP2L1,HER11,GPR37L1 |
Interacting Protein
ADA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADA here. Most of them are supplied by our site. Hope this information will be useful for your research of ADA.
PIAS2;SGCD;TINF2;TERF2IP
Resources
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References
- Zhang, JC; Yu, BB; et al. Non-Normal Random Effects Models for Immunogenicity Assay Cut Point Determination. JOURNAL OF BIOPHARMACEUTICAL STATISTICS 25:295-306(2015).
- Zandvliet, A; Glasgow, S; et al. Tildrakizumab, a novel anti-IL-23 monoclonal antibody, is unaffected by ethnic variability in Caucasian, Chinese, and Japanese subjects. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 53:139-146(2015).
