ACSL5
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Official Full Name
acyl-CoA synthetase long-chain family member 5 -
Overview
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
ACSL5;acyl-CoA synthetase long-chain family member 5;FACL5, fatty acid Coenzyme A ligase, long chain 5;long-chain-fatty-acid--CoA ligase 5;ACS2;ACS5;FACL5 for fatty acid coenzyme A ligase 5;fatty acid Coenzyme A ligase;long chain 5;long chain ac
Recombinant Proteins
- Zebrafish
- Human
- Chicken
- Rat
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- E.coli
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
ACSL5 involved in several pathways and played different roles in them. We selected most pathways ACSL5 participated on our site, such as Fatty acid biosynthesis,Fatty acid degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | CRAT,BAAT,HMGCL,NOS2B,PEX2,PRDX1,AGXTA,ANI_1_2390104,DDO,HMGCLL1 |
| Fatty acid degradation | CYP4A11,ADH7,ACSL4A,ACSL3B,ACAT1,ALDH9A1B,ALDH7A1,CPT2,ADH5,ACADM |
| Fatty Acid Biosynthesis | ACSL4A,ACACA,FASN,ACSBG2,ACSL3A,ACSL4,MCAT,ACSL1B,ACSL1A,ECHDC3 |
| PPAR signaling pathway | MMP1A,PDPK1,FABP5,PCK1,FABP3,UBC,LPL,RXRBA,PPARA,APOA2 |
| Fatty acid metabolism | PTPLAD1,ACACA,OXSM,ACOX3,ACSBG1,Scd2,CPT2,ACSL1A,PTPLA,ACSL1B |
| Metabolic pathways | UGT2B15,PGP,DPM1,GFPT1,QPRT,CBS,DPYD,NAPRT,CHIA.2,SYNJ1 |
| Adipocytokine signaling pathway | PRKAB1A,G6PC2,ACSL4,ACSL4B,ADIPOQB,ACSBG2,NFKBIAA,TNF,LEP,MAPK10 |
Protein Function
ACSL5 has several biochemical functions, for example, ATP binding,long-chain fatty acid-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL5 itself. We selected most functions ACSL5 had, and list some proteins which have the same functions with ACSL5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| long-chain fatty acid-CoA ligase activity | ACSL1,ACSBG2,SLC27A3,SLC27A1A,ACSL4,SLC27A2,ACSBG1,SLC27A5,SLC27A4,ACSL3 |
| ATP binding | KIF3B,PFKFB2A,MYHC4,RPS6KB1B,RECQL,EIF2AK3,ITPKC,FUK,NLRC5,NEK10 |
Interacting Protein
ACSL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL5.
CREB3;ogl;LRRK2
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References
- Saatchi, M; Beever, JE; et al. QTLs associated with dry matter intake, metabolic mid-test weight, growth and feed efficiency have little overlap across 4 beef cattle studies. BMC GENOMICS 15:-(2014).
- Wang, S; Matthan, NR; et al. Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in Mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. CLINICAL NUTRITION 33:260-266(2014).
