ACAT2
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Official Full Name
acetyl-CoA acetyltransferase 2 -
Overview
The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008] -
Synonyms
ACAT2;acetyl-CoA acetyltransferase 2;acetyl-CoA acetyltransferase, cytosolic;acetoacetyl Coenzyme A thiolase;cytosolic acetoacetyl-CoA thiolase;acetyl-CoA transferase-like protein
Recombinant Proteins
- Mouse
- Human
- Chicken
- Zebrafish
- Rat
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- His
- GST
- T7
- His&T7
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- His&Myc
Involved Pathway
ACAT2 involved in several pathways and played different roles in them. We selected most pathways ACAT2 participated on our site, such as Fatty acid degradation,Synthesis and degradation of ketone bodies,Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Synthesis and degradation of ketone bodies | HMGCLL1,OXCT2B,OXCT2A,OXCT2,HMGCL,BDH2,BDH1,HMGCS1,OXCT1A,ACAT1 |
| Butanoate metabolism | ACAT1,ACSM4,ACSM2,OXCT2A,GAD2,OXCT1,HADH,BDH1,OXCT1A,AACS |
| Fat digestion and absorption | ABCA1,PPAP2B,PLA2G12A,PNLIPRP1,PNLIPRP2,AGPAT2,PLA2G2A,APOB,PPAP2C,DGAT2 |
| Fatty acid metabolism | ACACA,HADHB,ACADVL,EHHADH,ELOVL6,CPT1B,ACOX3,PECR,ACADM,PTPLAD1 |
| Valine, leucine and isoleucine degradation | BCAT1,OXCT2B,AOX3,ALDH9A1A.1,HIBADH,HIBADHB,HIBCH,ALDH9A1,PCCA,ACAA1A |
| Metabolic pathways | CYP4F2,GGPS1,PGD,DUT,H2-KE6,PIGO,PON2,DHFRL1,UQCRC2,IDH3A |
| Tryptophan metabolism | AOX3,GCDHB,ALDH3A2A,AADAT,CAT,KMO,HADHAA,ACAT1,AANAT,DHCR24 |
| Fatty acid degradation | HADH,EHHADH,ACADS,ALDH2.2,ACSL3,ACSL4,CPT1B,ADH5,ACSBG1,HADHAB |
| Glyoxylate and dicarboxylate metabolism | PCCB,AMT,MDH2,HYI,ACAT1,GLUL,AGXT,GRHPRB,GLDC,AFMID |
Protein Function
ACAT2 has several biochemical functions, for example, acetyl-CoA C-acetyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAT2 itself. We selected most functions ACAT2 had, and list some proteins which have the same functions with ACAT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CUL5,PNKP,COASY,RRS1,DNAJA4,BBC3,SP3,SLAMF7,SCAF8,DNAJC28 |
| acetyl-CoA C-acetyltransferase activity | ACAA1A,HADHA,ACAT1 |
Interacting Protein
ACAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAT2.
LNX1;TERF1;EIF1B;VDAC1;MCC;HLA-B;GNAS;CCNA1;ATG5;FTSJ1;TNIK;PRKAB1;TRAF6
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References
- Sakashita, N; Miyazaki, A; et al. Acyl-coenzyme A : cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: In vivo and in vitro studies. LABORATORY INVESTIGATION 83:1569-1581(2003).
- Lin, S; Lu, XH; et al. Human acyl-coenzyme A : cholesterol acyltransferase expressed in Chinese hamster ovary cells: Membrane topology and active site location. MOLECULAR BIOLOGY OF THE CELL 14:2447-2460(2003).
