ACACA
-
Official Full Name
acetyl-CoA carboxylase alpha -
Overview
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. -
Synonyms
ACACA;acetyl-CoA carboxylase alpha;ACAC, ACC, acetyl Coenzyme A carboxylase alpha;acetyl-CoA carboxylase 1;ACC1;acetyl CoA carboxylase 1;ACC-alpha;acetyl-Coenzyme A carboxylase alpha;ACC;ACAC;ACCA;ACACAD
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- E.coli
- Insect Cell
- Mammalian Cell
- Wheat Germ
- Sf9 Insect Cell
- E.Coli or Yeast
- Yeast
- HEK293
- His
- His&Flag
- GST
- His&MBP
- His&GST
- His&Fc&Avi
Involved Pathway
ACACA involved in several pathways and played different roles in them. We selected most pathways ACACA participated on our site, such as Fatty acid biosynthesis,Pyruvate metabolism,Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACACA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling pathway | PFKP,G6PC,CD36,CREB1,PPP2R5C,CFTR,RPTOR,PCK2,PIK3CG,FOXO1 |
| Propanoate metabolism | DLDH,ALDH6A1,MCEE,HIBCH,LDHB,LDHBA,ACSS3,ACSS1,ACAT1,LDHBB |
| Fatty Acid Biosynthesis | ACSL1,OLAH,FASN,ACSL3A,ACSL1B,ACSL4,ACSL4A,ACAA2,ACSBG2,ACSL1A |
| Pyruvate metabolism | MDH1AA,FH1,GLO1,PDP2,PCK2,PKMA,ACAT2,BRP44,ALDH9A1,ACOT12 |
| Fatty acid metabolism | TECR,ACAA2,ACSL4B,HSD17B12B,PECR,EHHADH,ACSL3B,CPT1B,ACAT1,ACADS |
| Metabolic pathways | SMS,HOGA1,NME6,RDH8A,SPAM1,PGD,PTGIS,MIBP,SMPD3,SMPD2 |
| Insulin signaling pathway | CALM,PDPK1B,RAF1B,RPS6KB1B,PRKAB1B,TSC1,PYGL,TRIP10,CBLC,BAD |
Protein Function
ACACA has several biochemical functions, for example, ATP binding,acetyl-CoA carboxylase activity,biotin carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACACA itself. We selected most functions ACACA had, and list some proteins which have the same functions with ACACA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetyl-CoA carboxylase activity | ACACB |
| ATP binding | CDK1,KIF11,CHUK,CASKA,UBE2W,ATP6V1BA,MB21D1,P2RX3,MCM9,KIF22 |
| protein binding | GLE1,MATN4,CRABP2,BCAR1,BCL11A,GPRIN2,UPF3B,AHCYL1,CAMK2B,S100A8 |
| biotin carboxylase activity | MCCC1,ACACB,PCXA,PCXB,PCCA,PC |
| metal ion binding | FTH1B,PPP1CA,KDM5D,TRIM35-39,HEPHL1,HIVEP3,ACVR1B,BCL11AB,ZNF285A,TGM2A |
Interacting Protein
ACACA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACACA here. Most of them are supplied by our site. Hope this information will be useful for your research of ACACA.
SIRT1;AKR1B10;ILK;BRCA1;Mylk;CIAO1;MYC;MCC;CHGB;ATXN1;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;midostaurin;EEF2K
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