ABCB5
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Official Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 5 -
Overview
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins;participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions,;sugars, and peptides to more complex organic molecules (Chen et al., 2005 (PubMed 15760339)). -
Synonyms
ABCB5;ATP-binding cassette, sub-family B (MDR/TAP), member 5;ATP-binding cassette sub-family B member 5;ABCB5alpha;ABCB5beta;ATP binding cassette protein;EST422562;P glycoprotein ABCB5;ABCB5 P-gp;P-glycoprotein ABCB5;ATP-binding cassette protein
Recombinant Proteins
- Human
- Mouse
- Dictyostelium Discoideum
- E.coli
- E. coli
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- N-GST
- N-His
- Non
- His&Trx
- Trx
- His&Fc&Avi
Involved Pathway
ABCB5 involved in several pathways and played different roles in them. We selected most pathways ABCB5 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCB5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCC10,ABCB8,ABCB1A,ABCC1,ABCC4,ABCG8,ABCA4,ABCB4,CFTR,ABCB1LB |
Protein Function
ABCB5 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,efflux transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCB5 itself. We selected most functions ABCB5 had, and list some proteins which have the same functions with ABCB5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activity, coupled to transmembrane movement of substances | ABCD2,ABCG3,ABCA4,ABCB8,ABCG2D,ABCB4,DPY19L2,SFRP5,ABCC8,ABCB1A |
| ATP binding | CHTF18,ATP6V1BA,CMPK1,ERCC6,PAK2B,PMVK,ACVRL1,TEX14,TPK1,JAK1 |
| efflux transmembrane transporter activity | ABCB6,SLC26A6,SLC17A3 |
Interacting Protein
ABCB5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCB5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCB5.
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References
- Suzuki, N; Takata, M; et al. Assessment of Melanoma-Initiating Cell Markers and Conventional Parameters in Sentinel Lymph Nodes of Malignant Melanoma. ACTA MEDICA OKAYAMA 69:17-27(2015).
- Wong, NCL; Cheung, PFY; et al. Antibody against Granulin-Epithelin Precursor Sensitizes Hepatocellular Carcinoma to Chemotherapeutic Agents. MOLECULAR CANCER THERAPEUTICS 13:3001-3012(2014).
