IVD of Platanus acerifolia Allergy
Platanus acerifolia
Platanus acerifolia is one of the major sources of outdoor allergens and is capable of inducing allergic asthma, rhinitis, contact dermatitis, and other allergic diseases in humans. Currently, it is found that Platanus acerifolia allergen extract mainly contains three allergenic proteins, namely Pla a 1, Pla a 2, and Pla a 3. With the development of molecular biology technology, the use of genetic engineering to prepare recombinant allergens for clinical diagnosis, treatment, and research of allergic diseases has become one of the development directions of the allergy discipline. Recombinant allergens can lay the foundation for the subsequent transformation of hypoallergenic allergens and the acquisition of allergen nucleic acid vaccines.
Main Steps of IVD for Platanus acerifolia Allergy
- ImmunoCAP
The pollen extract of Platanus acerifolia was used as an antigen to react with the IgE antibody in the patient's serum, and then a fluorescently labeled secondary antibody was added. Finally, a CAP detector was used to detect the intensity of the fluorescence signal to determine whether the patient was allergic to sycamore pollen.
- Western blotting
The Platanus acerifolia pollen extract was subjected to SDS-PAGE electrophoresis, then transferred to a membrane for reaction with the patient's serum, and finally developed with enzyme-labeled secondary antibodies. This method can detect the presence of specific IgE antibodies against pollen in the patient's serum.
Creative BioMart provides high-quality recombinant Platanus acerifolia allergen proteins used for IVD, including ELISA, lateral flow assay, western blot, and other immunoassays.
Highlights of Our Products
- High purity. No contamination by external toxic agents or pathogenic microbes.
- High specificity and sensitivity. The molecular structure and biological activity of recombinant allergens are similar to natural allergens and can effectively stimulate immune responses in allergic patients.
- Easy to scale up production. Process amplification enables the acquisition of a multitude of specific proteins, without the restriction imposed by the content of natural extracts or materials.
- Higher safety and repeatability.
Our Outstanding Advantages
- Our company has a skilled technical team, state-of-the-art scientific research equipment, and cutting-edge technology to deliver unparalleled services.
- With a diverse range of IVD products, we cater to the varying needs of our clients and offer all-encompassing scientific research support.
- We strive to provide timely and accurate IVD-related services, ensuring that our customers receive the best scientific research experience possible.
Clinical Related Information
Major Allergen
The primary allergen associated with Platanus acerifolia is tree pollen. Pollen from the plane tree can cause allergic reactions in sensitive individuals, particularly during the flowering season.
Symptoms of Platanus acerifolia Allergy
People allergic to plane tree pollen may experience symptoms similar to those of hay fever.
- Runny nose and nasal congestion
- Watery, itchy, red eyes
- Sneezing
- Cough
- Itchy nose, roof of mouth, or throat
- Mucus running down the back of the throat (postnasal drip)
- Swollen, bruised-appearing skin under the eyes (allergic shiners)
- Extreme tiredness and fatigue, often due to poor sleep
How to Overcome Platanus acerifolia Allergy
Avoidance:
- Stay indoors on dry, windy days when pollen counts are high.
- Close doors and windows during pollen season.
- Use air conditioning in your house and car.
- Avoid outdoor activities in the early morning when pollen counts are highest.
Medications:
- Antihistamines: Help reduce sneezing, itching, and runny nose.
- Decongestants: Provide temporary relief of nasal stuffiness.
- Nasal corticosteroids: Reduce inflammation and are a highly effective treatment for hay fever.
- Nasal irrigation: Using saline solutions to flush out allergens from the nasal passages.
Immunotherapy:
Allergy shots: Gradual administration of increasing doses of the allergen to build tolerance.
Sublingual Immunotherapy (SLIT): Tablets or drops placed under the tongue.
Lifestyle and Home Remedies:
- Shower and wash your hair after being outdoors.
- Wear a mask while gardening or mowing the grass.
- Monitor pollen counts and limit outdoor activities when levels are high.
Case Study
Case 1: Garriga-Baraut T, Moncín MMSM, Tena M, Labrador-Horrillo M; Comitè d'Al·lèrgia Respiratòria de Catalunya, Spain. INMUNOCAT study: The impact of molecular diagnosis on immunotherapy prescription in pollen polysensitized patients from Catalonia. Clin Transl Allergy. 2023 May;13(5):e12246. doi: 10.1002/clt2.12246. PMID: 37227418; PMCID: PMC10154984.
Fig2. Pollen sensitization profile of the cohort. (A), Frequency of positive reactions to most common allergens across age groups, according to skin prick tests. (B), Frequency of positive reactions to the most common molecular allergens according to ImmunoCAP® ISAC; allergens were classified into: specific allergens (leading to genuine sensitization) and cross‐reactive allergens.