ZEB1

  • Product List
  • Overview
  • Review / Q&A
  • Official Full Name

    zinc finger E-box binding homeobox 1
  • Overview

    This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms

    ZEB1;zinc finger E-box binding homeobox 1;posterior polymorphous corneal dystrophy 3 , PPCD3, TCF8, transcription factor 8 (represses interleukin 2 expression);zinc finger E-box-binding homeobox 1;AREB6;BZP;NIL 2 A;ZEB;Zfhep;Zfhx1a;AREB 6;DELTA EF1;MGC133261;Negative regulator of IL 2;Negative regulator of IL2;NIL 2 A zinc finger protein;NIL 2A;NIL-2-A zinc finger protein;NIL2A;Represses interleukin 2 expression;TCF 8;TCF-8;TCF8;Transcription factor 8 (represses interleukin 2 expression);Transcription factor 8;ZEB 1;ZEB1_HUMAN;ZFHX 1A;Zinc finger E box binding homeobox 1;Zinc finger homeodomain enhancer binding protein;OTTHUMP00000019404;OTTHUMP00000019405;OTTHUMP00000019406;delta-crystallin enhancer binding factor 1;posterior polymorphous corneal dystrophy 3;zinc finger homeodomain enhancer-binding protein;FECD6;PPCD3;DELTAEF1

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ZEB1-3796H Recombinant Human ZEB1, GST-tagged E.coli Human GST 391-740aa
ZEB1-18798M Recombinant Mouse ZEB1 Protein Mammalian Cells Mouse His
ZEB1-22H Recombinant Human ZEB1 Protein, GST-tagged Wheat Germ Human GST 801 a.a. - 900 a.a.
ZEB1-6688C Recombinant Chicken ZEB1 Mammalian Cells Chicken His
ZEB1-190HCL Recombinant Human ZEB1 293 Cell Lysate HEK293 Human Non
ZEB1-10324M Recombinant Mouse ZEB1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ZEB1-10324M-B Recombinant Mouse ZEB1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ZEB1-604H Recombinant Human ZEB1 Protein, His-tagged E.coli Human His Tyr904-Ala1124

Involved Pathway

ZEB1 involved in several pathways and played different roles in them. We selected most pathways ZEB1 participated on our site, such as Transcriptional misregulation in cancer,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZEB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Transcriptional misregulation in cancer H3F3C,MDM2,RUNX1T1,Itgam&Itgb2,SS18,WT1,MLF1,Pdgfa&Pdgfb,GOLPH3L,MLLT3
MicroRNAs in cancer ABCB1,CCNE1,BAK1,TP63,WNT3,KRAS,UBE2I,ERBB2,DNMT3B,DICER1

Protein Function

ZEB1 has several biochemical functions, for example, E-box binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZEB1 itself. We selected most functions ZEB1 had, and list some proteins which have the same functions with ZEB1. You can find most of the proteins on our site.

Function Related Protein
transcription factor activity, sequence-specific DNA binding MAFGB,SKINT8,ZSCAN4D,TBX1,TAF6,RCOR2,STAT6,HOXB7A,NFIL3,NKX6-2
transcription factor binding CCND1,TFDP2,NFIA,TAF1,TAF7,ZBTB49,DRG1,HYAL1,POU5F1,ARNT
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding SATB1,ISX,KLF12,HOXD9,BCL6AB,BCL6,MITF,ARHGAP35,POU5F1,MNT
chromatin binding EGFR,MECP2,SFPQ,CREB3,POLR2B,KLF14,LHX2,MEOX1,TPR,UBTFL
protein binding ALDOB,TIMP2,FTH1,CD59,GLA,STAP1,SPATA22,PSMD6,SLC6A12,ATXN3
transcription corepressor activity CBFA2T2,ATF7IP,LHX9,NSD1,CCAR1,HOMEZ,ZFPM1,ZNF593,PFDN5,HOXC6
E-box binding TFAP4,MYOD1,TCF21,ARNTL2,TWIST1,AHR,NEUROD2,LMO2,MYC,NEUROG2
zinc ion binding PRICKLE2A,ZNRD1,RFPL2,XAF1,L3MBTL2,MDM2,TRIM23,NR1H5,ZNRF1,NEURL1AA
transcription coactivator activity DDX5,NR1I3,CEBPA,TFDP1,MED21,CRSP7,TFAP2A,NCOA4,GTF2A1L,KAT2B

Interacting Protein

ZEB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZEB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZEB1.

CDK6;CTBP1;yscH;ifnl1_human_gene;SYNCRIP

Resources

References

  • Gamba, CO; Campos, LC; et al. ZEB2 and ZEB1 expression in a spontaneous canine model of invasive micropapillary carcinoma of the mammary gland. RESEARCH IN VETERINARY SCIENCE 97:554-559(2014).
  • Lee, JH; Nam, H; et al. Upregulation of GM-CSF by TGF-beta 1 in epithelial mesenchymal transition of human HERS/ERM cells. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 50:399-405(2014).

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