XRCC4
-
Official Full Name
X-ray repair complementing defective repair in Chinese hamster cells 4 -
Overview
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. -
Synonyms
XRCC4;X-ray repair complementing defective repair in Chinese hamster cells 4;DNA repair protein XRCC4;X ray repair;complementing defective;repair in Chinese hamster;X-ray repair cross-complementing protein 4;X-ray repair, complementing defective, r
Recombinant Proteins
- Human
- Cynomolgus
- Zebrafish
- Mouse
- E.coli
- HEK293
- Mammalian Cells
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
XRCC4 involved in several pathways and played different roles in them. We selected most pathways XRCC4 participated on our site, such as Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-homologous end-joining | POLL,NHEJ1,MRE11A,LIG4,PRKDC,FEN1,XRCC5,DCLRE1C,POLM,DNTT |
Protein Function
XRCC4 has several biochemical functions, for example, NOT DNA binding,NOT ligase activity,protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC4 itself. We selected most functions XRCC4 had, and list some proteins which have the same functions with XRCC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | CTGF,CORO1A,SNX17,ERBB2,PEX16,VGLL3,ITGB3BP,DAB2,CTNNB1,MIF4GD |
| NOT DNA binding | TINF2,SKIL,NFIB,HIPK2,MBD5 |
| protein binding | CNOT7,SNX32,PRSS21,TOB1A,TPI1,ZNF26,INTS3,PLXDC1,IRF7,GUCY1B3 |
Interacting Protein
XRCC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC4.
PNKP;NHEJ1;APLF
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References
- Vignard, J; Mirey, G; et al. Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up. RADIOTHERAPY AND ONCOLOGY 108:362-369(2013).
- Palomino, GM; Bassi, CL; et al. Patients with Systemic Sclerosis Present Increased DNA Damage Differentially Associated with DNA Repair Gene Polymorphisms. JOURNAL OF RHEUMATOLOGY 41:458-465(2014).
