XRCC2
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Official Full Name
X-ray repair complementing defective repair in Chinese hamster cells 2 -
Overview
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. -
Synonyms
XRCC2;X-ray repair complementing defective repair in Chinese hamster cells 2;DNA repair protein XRCC2;RAD51 like;X-ray repair cross-complementing protein 2;X-ray repair, complementing defective, repair in Chinese hamster;DKFZp781P0919
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| XRCC2-18636M | Recombinant Mouse XRCC2 Protein | Mammalian Cell | Mouse | His |
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| XRCC2-412H | Recombinant Human X-ray repair complementing defective repair in Chinese hamster cells 2, His-tagged | E.coli | Human | His | 1-280 a.a. |
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| XRCC2-5013H | Recombinant Human XRCC2, His-tagged | E.coli | Human | His |
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| XRCC2-257HCL | Recombinant Human XRCC2 293 Cell Lysate | HEK293 | Human | Non |
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| XRCC2-10240M | Recombinant Mouse XRCC2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| XRCC2-10240M-B | Recombinant Mouse XRCC2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| XRCC2-3240H | Recombinant Human XRCC2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Xrcc2-7023M | Recombinant Mouse Xrcc2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
XRCC2 involved in several pathways and played different roles in them. We selected most pathways XRCC2 participated on our site, such as Homologous recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Homologous recombination | BLM,CDK5R2,FUZ,BRCA2,MUS81,SHFM1,RPA4,POLD2,RAD54B,XRCC3 |
Protein Function
XRCC2 has several biochemical functions, for example, ATP binding,DNA-dependent ATPase activity,double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC2 itself. We selected most functions XRCC2 had, and list some proteins which have the same functions with XRCC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| single-stranded DNA binding | RPA4,CNBPA,HNRNPDL,ERCC4,MCM7,NUP35,TSN,RAD23B,TDP2B,SSBP2 |
| contributes_to endodeoxyribonuclease activity | RAD51D,RAD51B,DMC1,RAD51L3,ERCC4,RAD51,RAD51L1 |
| double-stranded DNA binding | XRCC3,MTERFD1,DMC1,GTF2H4,RAD51L3,HMGB3,HMGB1,CSDA,HLF,YBX1 |
| ATP binding | PKN1B,VPRBP,LRRK1,MYH7,CSNK2A2,WRNIP1,CDK19,ERBB2,KIF12,HSPE1 |
| protein binding | MARCH10,NR4A3,HELLS,PARK7,RHOT2,GNA12,BAX,CENPI,RNF168,NFKB1 |
| recombinase activity | XRCC3,RAD51B,RAD51,RAD51L1,RAD51L3,RAD51C,DMC1,RBPJ,RAD51D |
| DNA-dependent ATPase activity | SMARCA2,DHX36,DDX11,XRCC3,MSH3,IGHMBP2,TOP2A,MSH6,SMARCAL1,ERCC2 |
| contributes_to four-way junction DNA binding | RAD51L3,MSH6,MSH2,RAD51L1,RAD51D,XRCC3,RAD51B,RAD51C |
Interacting Protein
XRCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC2.
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