XPA
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Official Full Name
xeroderma pigmentosum, complementation group A -
Overview
DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene. This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
XPA;xeroderma pigmentosum, complementation group A;DNA repair protein complementing XP-A cells;XP1;XPAC;excision repair-controlling;xeroderma pigmentosum group A-complementing protein
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- His&GST
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| XPA-3751H | Recombinant Human XPA, His-tagged | E.coli | Human | His | C-term-273aa | |
| XPA-10771Z | Recombinant Zebrafish XPA | Mammalian Cell | Zebrafish | His |
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| XPA-18625M | Recombinant Mouse XPA Protein | Mammalian Cell | Mouse | His |
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| XPA-6416C | Recombinant Chicken XPA | Mammalian Cell | Chicken | His |
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| XPA-7232H | Recombinant Human XPA, His-tagged | E.coli | Human | His | 1-273aa |
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| XPA-262HCL | Recombinant Human XPA 293 Cell Lysate | HEK293 | Human | Non |
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| XPA-10232M | Recombinant Mouse XPA Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| XPA-10232M-B | Recombinant Mouse XPA Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| XPA-594H | Recombinant Human XPA Protein, His&GST-tagged | E.coli | Human | His&GST | Ser23-Glu271 |
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| XPA-6719H | Recombinant Human XPA Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Xpa-7017M | Recombinant Mouse Xpa Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
XPA involved in several pathways and played different roles in them. We selected most pathways XPA participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | KIAA1530,ACTR5,ERCC8,RPA2,ERCC2,COPS2,INO80B,GTF2H5,POLE3,GTF2H2C |
Protein Function
XPA has several biochemical functions, for example, damaged DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XPA itself. We selected most functions XPA had, and list some proteins which have the same functions with XPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAM119A,THBS1,STAG3,RUSC1-AS1,MYO7B,MARVELD3,INIP,MLF1IP,VPS37B,NIPAL3 |
| damaged DNA binding | RPA2,XRCC6,EP300,RPA3,NEIL3,ERCC1,RBBP8,POLI,XRCC1,BRCA1 |
| metal ion binding | MBNL1,ZNF740,ZNFX1,KCNH7,POLR2A,PLA2G4F,WBSCR17,NEURL1AB,TRIM35-27,MORC2A |
| protein domain specific binding | HOXB1,PRKCZ,TNFAIP1,GNAI3,PPP3R1,RAB27B,ARFIP2B,DYNLL1,TADA3,YWHAG1 |
| protein homodimerization activity | Il6ra,AOC3,VIL1,ERBB3,SLK,VPS4B,SETMAR,CARS,HINT2,IRAK3 |
Interacting Protein
XPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPA here. Most of them are supplied by our site. Hope this information will be useful for your research of XPA.
RPA2;SIRT1;ERCC1;TRIM27;NDEL1
Resources
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References
- Ahmad, I; Simanyi, E; et al. Toll-Like Receptor-4 Deficiency Enhances Repair of UVR-Induced Cutaneous DNA Damage by Nucleotide Excision Repair Mechanism. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:1710-1717(2014).
- Aufderklamm, S; Hennenlotter, J; et al. XPA-210: a new proliferation marker determines locally advanced prostate cancer and is a predictor of biochemical recurrence. WORLD JOURNAL OF UROLOGY 30:547-552(2012).
