WTAP
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Official Full Name
Wilms tumor 1 associated protein -
Overview
The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform. -
Synonyms
WTAP;Wilms tumor 1 associated protein;pre-mRNA-splicing regulator WTAP;KIAA0105;MGC3925;hFL(2)D;PNAS-132;WT1-associated protein;female-lethal(2)D homolog;wilms tumor 1-associating protein;Wilms tumour 1-associating protein;putative pre-mRNA spl
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- Insect Cell
- HEK293
- HEK293T
- GST
- His
- T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
WTAP involved in several pathways and played different roles in them. We selected most pathways WTAP participated on our site, such as Gene Expression,Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with WTAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Processing of Capped Intron-Containing Pre-mRNA | PRPF8,TXNL4A,U2AF2,HNRNPA0L,SNRNP35,SNRNP25,PTBP1,SF3B2,DNAJC8,SF3B4 |
| Gene Expression | RPP30,ZNF483,SNAPC2,ZNF133,RBM5,ZNF92,SUPT16H,ZKSCAN5,CSTF1,ZNF136 |
Protein Function
WTAP has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WTAP itself. We selected most functions WTAP had, and list some proteins which have the same functions with WTAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | IL1A,RBL1,RPAP3,SLIRP,MIS18BP1,KRTAP10-8,AKAP12,MCCC2,AP1M1,RNF216 |
Interacting Protein
WTAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WTAP here. Most of them are supplied by our site. Hope this information will be useful for your research of WTAP.
IKZF1;VPS52;YWHAZ;MAGEA11;TAB1;Sod1;Srsf1;METTL3
Resources
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References
- Venkatareddy, M; Wang, S; et al. Estimating Podocyte Number and Density Using a Single Histologic Section. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 25:1118-1129(2014).
- Leader, R; Deol-Poonia, RK; et al. Immunohistochemical localization of WT1 in epithelial salivary tumors. PATHOLOGY RESEARCH AND PRACTICE 210:726-732(2014).
