WNT16
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Official Full Name
wingless-type MMTV integration site family, member 16 -
Overview
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5 termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008] -
Synonyms
WNT16;wingless-type MMTV integration site family, member 16;protein Wnt-16;wingless-type MMTV integration site family member 16b
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Human Cells
- Mammalian Cells
- HEK293
- E.coli
- Strep II
- His
- Non
- GST
- Flag
- DDK
- Myc
- Avi
- Fc
Involved Pathway
WNT16 involved in several pathways and played different roles in them. We selected most pathways WNT16 participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | HSPG2,RDX,GPC1,CAV1,PTPN6,MAPK1,WNT6,BRAF,GAB1,PTCH1 |
| Hippo signaling pathway | NKD1,FZD2,FZD9,BBC3,WTIP,ITGB2,BMP4,PPP2R1B,JUB,WNT9A |
| HTLV-I infection | TBPL1,ZFP36,FZD6,ANAPC7,IL2RG,NFYB,CALR,ANAPC5,ANAPC4,WNT11 |
| Melanogenesis | GNAI2A,KIT,FZD8B,EDNRBA,CALM,WNT4,HRAS,WNT2B,ADCY1B,FZD8 |
| Pathways in cancer | Casp3,FZD5,GSK3B,LAMB4,F2R,LAMC1,TRAF2,RAD51,IL-8,Ar |
| Wnt signaling pathway | MYCB,PPARDB,DAAM1,FZD3A,WNT9A,SOST,CAMK2G1,SOX17,WNT4,CAMK2A |
| Signaling pathways regulating pluripotency of stem cells | ACVR1C,SMAD5,Fzd4,JARID2,HESX1,MAPK13,FZD5,INHBE,FZD7,LHX5 |
| Hedgehog signaling pathway | GLI2B,CSNK1A1L,DHH,WNT5A,CSNK1G1,WNT4A,WNT8A,STK36,BTRC,WNT9A |
| Basal cell carcinoma | WNT7A,WNT8A,FZD6,SETD6,WNT7B,TRP53,PTCH2,FZD8,APC2,WNT5B |
Protein Function
WNT16 has several biochemical functions, for example, frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT16 itself. We selected most functions WNT16 had, and list some proteins which have the same functions with WNT16. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| frizzled binding | WNT2,ZNRF3,WNT11R,FZD7,DVL2,WNT4,WNT2BA,WNT5B,DVL1B,CTHRC1 |
Interacting Protein
WNT16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT16 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT16.
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