WISP3
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Official Full Name
WNT1 inducible signaling pathway protein 3 -
Overview
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
WISP3;WNT1 inducible signaling pathway protein 3;WNT1-inducible-signaling pathway protein 3;CCN6;WISP-3;CCN family member 6;PPD;LIBC;PPAC;MGC125987;MGC125988;MGC125989
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Non
- His
- Fc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| WISP3-184H |
Active Recombinant Human WNT1 Inducible Signaling Pathway Protein 3
|
E.coli | Human | Non |
|
|
| WISP3-530H |
Active Recombinant Human WISP3 Protein
|
E.coli | Human | Non |
|
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| WISP3-18557M | Recombinant Mouse WISP3 Protein | Mammalian Cell | Mouse | His |
|
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| WISP3-31250TH | Recombinant Human WISP3, Fc-tagged | E.coli | Human | Fc |
|
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| WISP3-7601Z | Recombinant Zebrafish WISP3 | Mammalian Cell | Zebrafish | His |
|
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| WISP3-306HCL | Recombinant Human WISP3 293 Cell Lysate | HEK293 | Human | Non |
|
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| WISP3-10185M | Recombinant Mouse WISP3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
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| WISP3-10185M-B | Recombinant Mouse WISP3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
WISP3 involved in several pathways and played different roles in them. We selected most pathways WISP3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WISP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
WISP3 has several biochemical functions, for example, growth factor activity,heparin binding,insulin-like growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WISP3 itself. We selected most functions WISP3 had, and list some proteins which have the same functions with WISP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | Artn,GDNF,FGF8A,AMH,PROK1,CECR1,LFT1,PRL2C3,GMFB,CSF2 |
| integrin binding | CTGFA,THBS4,VTN,ACTN2,IGF1,L1CAM,ITGA3,ICAM3,CIB2,TIMP2 |
| insulin-like growth factor binding | CTGF,CYR61L1,KAZALD2,IGFBP1B,KAZALD3,IGFBP5A,WISP1B,HTRA3,ESM1,IGFBP3 |
| heparin binding | FGFBP1,C6orf25,TENM1,NOV,HBEGF,LIPI,IMPG2,COMP,CCL2,FGFR1A |
Interacting Protein
WISP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WISP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of WISP3.
Resources
Research Area
IGF Binding Protein & RegulatorBreast Cancer Biomarkers
Colon Cancer Biomarkers
Gastric Cancer Biomarkers
Related Services
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References
