WIBG

  • Official Full Name

    within bgcn homolog

  • Overview

    Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.

  • Synonyms

    WIBG;within bgcn homolog (Drosophila);partner of Y14 and mago;PYM;protein wibg homolog;MGC13064

Recombinant Proteins

  • Zebrafish
  • Mouse
  • Human
  • Rhesus macaque
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
WIBG-10872Z Recombinant Zebrafish WIBG Mammalian Cells Zebrafish His
WIBG-18548M Recombinant Mouse WIBG Protein Mammalian Cells Mouse His
WIBG-2771H Recombinant Human Within Bgcn Homolog (Drosophila), His-tagged E.coli Human His
WIBG-30861TH Recombinant Human WIBG, His-tagged E.coli Human His 204 amino acids
WIBG-5215R Recombinant Rhesus monkey WIBG Protein, His-tagged Mammalian Cells Rhesus macaque His
WIBG-312HCL Recombinant Human WIBG 293 Cell Lysate HEK293 Human Non
WIBG-10180M Recombinant Mouse WIBG Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
WIBG-10180M-B Recombinant Mouse WIBG Protein Pre-coupled Magnetic Beads HEK293 Mouse
WIBG-5028R Recombinant Rhesus Macaque WIBG Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
WIBG-5028R-B Recombinant Rhesus Macaque WIBG Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    WIBG involved in several pathways and played different roles in them. We selected most pathways WIBG participated on our site, such as RNA transport,mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WIBG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mRNA surveillance pathway NXF2,PABPC5,RNMT,EIF4A3,SSU72,RBM8A,MSI1,NXF3,HBS1L,PABPC1L2A
    RNA transport GEMIN6,EIF3H,MAGOH2,NUP107,EIF3JB,EIF3JA,EIF3BA,FMR1,RANBP2,SUMO4

    Protein Function

    WIBG has several biochemical functions, for example, poly(A) RNA binding,protein binding,ribosome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WIBG itself. We selected most functions WIBG had, and list some proteins which have the same functions with WIBG. You can find most of the proteins on our site.

    Function Related Protein
    ribosome binding ABCF1,EIF2A,CPEB1A,OLA1,EIF5A2,EFTUD1,ICT1,CPEB4,RICTOR,ETF1
    poly(A) RNA binding CCT3,RPS3,EIF4A2,MTAP4,HSP90AB1,DDX39,KPNB1,PSMD4,NPM3,FAM103A1
    protein binding ZNF572,TCAP,SYTL1,RRM2B,PICALM,PDCL,ZNF239,MB21D2,ABCF1,LRRC4

    Interacting Protein

    WIBG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WIBG here. Most of them are supplied by our site. Hope this information will be useful for your research of WIBG.

    RBM8A;MAGOH;b2r9y1_human;icp27_hhv8p

    Resources

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