VRK2
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Official Full Name
vaccinia related kinase 2 -
Overview
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene. -
Synonyms
VRK2;vaccinia related kinase 2;serine/threonine-protein kinase VRK2;2810003O05Rik;AI447698;EC 2.7.11.1;Serine/threonine protein kinase VRK2;Vaccinia virus B1R related kinase 2;Vaccinia-related kinase 2;VRK 2;VRK2_HUMAN;OTTHUMP00000159702;OTTHUMP00000201223;OTTHUMP00000201224;OTTHUMP00000225744;vaccinia virus B1R-related kinase 2
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Mus musculus
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
VRK2 involved in several pathways and played different roles in them. We selected most pathways VRK2 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Clearance of Nuclear Envelope Membranes from Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with VRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CENPA,ORC4,NDE1,ANAPC2,SFN,ESCO1,TUBGCP4,DYNC1H1,TP53,LEMD3 |
| Cell Cycle, Mitotic | CENPQ,KNTC1,CCDC99,INCENP,ESCO1,NDEL1B,MIS12,USO1,NUPL2,DSN1 |
| M Phase | CTDNEP1B,CNEP1R1,PDS5A,PDS5B,NDC80,SETB,NIPBLA,GORASP1,NCAPG2,NSL1 |
| Mitotic Prophase | BLZF1,ENSAA,MASTL,ARPP19A,TMEM188,PHF8,NEK7,SETA,MCPH1,SMC2 |
| Clearance of Nuclear Envelope Membranes from Chromatin | BANF1,TMPO,LEMD3,VRK1 |
| Mitotic Metaphase and Anaphase | NDEL1,NUDC,MIS12,NUF2,B9D2,KNTC1,ITGB3BP,ZWINT,PANE1,CENPI |
| Mitotic Anaphase | DSN1,CDCA5,TMPO,NDEL1A,SKA1,PMF1,SPC25,INCENP,CLIP1,SKA2 |
| Initiation of Nuclear Envelope Reformation | VRK1,TMPO,ANKLE2,LEMD3 |
Protein Function
VRK2 has several biochemical functions, for example, ATP binding,protein binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VRK2 itself. We selected most functions VRK2 had, and list some proteins which have the same functions with VRK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | GNAI3,SHC4,TUBA1A,IST1,ERCC1,STMN3,LAMP1,TRIM11,DRD3,PTPN11 |
| protein serine/threonine kinase activity | TRPM6,PRKCHA,MAPK8A,LATS2,RAF1A,PRKACBA,LMTK3,NEK10,MAPK6,NEK1 |
| ATP binding | MAPK12A,PIM2,ASNA1,CHD1L,GSK3AA,PEX6,SMARCA5,CMPK2,P2RY2,UBE2G2 |
| protein binding | ZNF792,FGB,RAB9B,NCF2,CLN6,TH1L,GMCL1,PAEP,PAGE5,NCOA2 |
| protein kinase binding | PIFO,CDH2,DNAJC3,HDAC7A,STX1B,APC,PRKAG3,KCNQ3,FGR,CCNK |
Interacting Protein
VRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of VRK2.
KSR1;ear_ebvb9;MAP2K1;COIL;Mapk8ip1;MAP3K7;BCL2;CDC42;Ktn1;ILK
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References
- RAY, MK; CHAKRABORTY, A; et al. CHARACTERISTICS OF THE EUKARYOTIC INITIATION FACTOR-II ASSOCIATED 67-KDA POLYPEPTIDE. BIOCHEMISTRY 32:5151-5159(1993).
- FULLER, CM; HOWARD, MB; et al. ANTIBODIES AGAINST THE CYSTIC-FIBROSIS TRANSMEMBRANE REGULATOR. AMERICAN JOURNAL OF PHYSIOLOGY 262:C396-C404(1992).
- Galmiche, MC; Rindisbacher, L; et al. Expression of a functional single chain antibody on the surface of extracellular enveloped vaccinia virus as a step towards selective tumour cell targeting. JOURNAL OF GENERAL VIROLOGY 78:3019-3027(1997).
- ISHIBASHI, T; BOTTARO, DP; et al. EXPRESSION CLONING OF A HUMAN DUAL-SPECIFICITY PHOSPHATASE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89:12170-12174(1992).
