VPS18
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Official Full Name
vacuolar protein sorting 18 homolog (S. cerevisiae) -
Overview
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. -
Synonyms
VPS18;vacuolar protein sorting 18 homolog (S. cerevisiae);vacuolar protein sorting protein 18;vacuolar protein sorting-associated protein 18 homolog;KIAA1475;PEP3;hVPS18;Vacuolar protein sorting 18;OTTHUMP00000160630
Recombinant Proteins
- Chicken
- Rhesus macaque
- Zebrafish
- Human
- Mammalian Cell
- HEK293
- E. coli
- His
- Non
- N-SUMO & C-His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| VPS18-4445C | Recombinant Chicken VPS18 | Mammalian Cell | Chicken | His |
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| VPS18-5166R | Recombinant Rhesus monkey VPS18 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| VPS18-9519Z | Recombinant Zebrafish VPS18 | Mammalian Cell | Zebrafish | His |
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| VPS18-397HCL | Recombinant Human VPS18 293 Cell Lysate | HEK293 | Human | Non |
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| VPS18-20H | Recombinant Human VPS18 protein, His-tagged | E. coli | Human | N-SUMO & C-His | Arg821-Leu970 |
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| VPS18-4979R | Recombinant Rhesus Macaque VPS18 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| VPS18-4979R-B | Recombinant Rhesus Macaque VPS18 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
VPS18 involved in several pathways and played different roles in them. We selected most pathways VPS18 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
VPS18 has several biochemical functions, for example, actin binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS18 itself. We selected most functions VPS18 had, and list some proteins which have the same functions with VPS18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| syntaxin binding | VAMP7,STX16,CPLX3A,SYT11A,NAPAA,SYT5,SYT16,STXBP3A,CPLX4C,STXBP3 |
| protein binding | ITGAV,EPS8L1,GPRASP2,FOXC2,LSM7,MGST1,ATRNL1,APTX,TMX3,PICALM |
| metal ion binding | ZFP426,MOBKL1A,LHX2A,PHOSPHO2,ZFP287,LMAN1,NR1D4A,FGG,SNAI1,ENTPD7 |
| protein binding, bridging | FSCN3,CAV2,CNTLN,BCL3,LOR,NMD3,GATAD2A,TRIM22,WWC1,MEN1 |
| actin binding | Fert2,VASP,MYLK,CAPG,LMOD1,KLHL4,KLHL20,CALD1B,MICAL2B,SMYHC1 |
Interacting Protein
VPS18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS18 here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS18.
VPS16;VPS11
Resources
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References
- Sato, TK; Rehling, P; et al. Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion. MOLECULAR CELL 6:661-671(2000).
