VCP
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Official Full Name
valosin containing protein -
Overview
Valosin-containing protein (VCP) is a highly conserved and abundant 97 kDa protein that belongs to the AAA (ATPase associated with a variety of cellular activities) family of proteins. VCP assembles as a homo-hexamer, forming a ring with a channel at its -
Synonyms
VCP;valosin containing protein;transitional endoplasmic reticulum ATPase;IBMPFD;p97;TER ATPase;yeast Cdc48p homolog;valosin-containing protein;15S Mg(2+)-ATPase p97 subunit;TERA;ALS14;MGC8560;MGC131997;MGC148092
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- GST
- His
- Myc&DDK
- His&T7
- Non
- His&Fc&Avi
- Flag
Involved Pathway
VCP involved in several pathways and played different roles in them. We selected most pathways VCP participated on our site, such as Protein processing in endoplasmic reticulum,Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VCP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | SAR1A,DNAJC3,UFD1L,UBE2D1,MAPK10,GSBP9,CALR3B,UBE2D2,HSP26,CUL1A |
| Legionellosis | CYCS,TLR4,IL-8,BNIP3,HSPA1A,EEF1A2,MYD88,Casp3,RAB1B,NLRC4 |
Protein Function
VCP has several biochemical functions, for example, ADP binding,ATP binding,ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VCP itself. We selected most functions VCP had, and list some proteins which have the same functions with VCP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MASP2,FGFRL1A,GPBP1,PPIL2,NOL4,UBAP2L,AMELX,DPYSL4,BTRC,MYO7B |
| ADP binding | MYO3A,MYO18A,GCLC,TAP1,ME1,MYO9B,P2RY1,HSP104,APAF1,ADCK3 |
| protein domain specific binding | PLXND1,GNAI3,HIST1H4B,CALM1,HIST1H4I,CA,TJP2,SHC4,EZR,EFS |
| ATPase activity | KIF9,CARNS1,KIF12,MLH1,PICK1,CLPX,HSP90AA1,ATP13A3,INO80,HAND2 |
| polyubiquitin binding | UBQLN1,BRE,UBQLN4,DZIP3,EPS15,ZFAND6,PSMD4,THRSP,DNAJB2,BAG6 |
| BAT3 complex binding | SGTA,USP13,AMFR |
| ubiquitin-like protein ligase binding | DDRGK1,CDK5RAP3,TRIP4,CEBPB,USP13 |
| lipid binding | AP2M1B,MTTP,ACOT11,APOH,GLTP,ALOX8,OSBPL11,ATP5G3,FFAR3,APOA4B.2 |
| protein phosphatase binding | PPARG,STAT6,JUPA,HSP90B1,Itga10&Itgb1,JAK3,FLT4,CSK,ANAPC5,RPA3 |
Interacting Protein
VCP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCP here. Most of them are supplied by our site. Hope this information will be useful for your research of VCP.
ATXN3;NSFL1C;UBXN6
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References
- Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
- Mori, F; Watanabe, Y; et al. Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: An immunohistochemical investigation of two cases. NEUROPATHOLOGY 34:140-147(2014).
