VAV3

  • Official Full Name

    vav 3 guanine nucleotide exchange factor

  • Overview

    The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels. As a signalling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein. Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response.

  • Synonyms

    VAV3;vav 3 guanine nucleotide exchange factor;vav 3 oncogene;guanine nucleotide exchange factor VAV3;VAV-3;FLJ40431

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag
  • GST

    Involved Pathway

    VAV3 involved in several pathways and played different roles in them. We selected most pathways VAV3 participated on our site, such as cAMP signaling pathway,Chemokine signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAV3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Natural killer cell mediated cytotoxicity TNF,IFNA4,BID,SH2D1A,KIR2DS3,NFATC1,NCR2,MAPK3,BRAF,SHC1
    Focal adhesion BCL2A,PPP1CC,CAPN2A,ITGB1B.2,PIK3R3B,MYLK3,COL4A2,RAF1A,PPP1CAB,RAC1A
    Regulation of Actin Cytoskeleton RAC3B,FGF19,FGF10,RHOAB,WAS,PIK3R1,ITGA4,MYLK3,MYL12.2,ITGA1
    Fc epsilon RI signaling pathway PIK3R3,PDPK1,HRAS,LCP2,AKT1,RAC1,MAP2K4,PLA2G4D,VAV1,IL3
    Fc gamma R-mediated phagocytosis VASP,PAK1,PLCG2,PIK3R1,SPHK2,PPAP2A,VAV1,PLD2,WASF3,SCIN
    Leukocyte transendothelial migration PRKCA,CXCR4,ITGB1,MYL9,CLDN4,CLDN11,CD99,NCF4,RASSF5,CTNNA3
    cAMP signaling pathway OXTR,MAPK8,FOS,NFKB1,FXYD1,TSHR,MAPK9,TNNI3,GRIA4,GRIN2C
    T cell receptor signaling pathway TNF,PIK3R2,DLG1,NFATC2,MAPK9,OXSR1A,SHB,IL5,CD8A,CABIN1
    Chemokine signaling pathway RELA,HRAS,JAK2,GM2506,ARRB2,PLCB3,LYN,CCL26,PRKACG,NFKBIA

    Protein Function

    VAV3 has several biochemical functions, for example, Rac guanyl-nucleotide exchange factor activity,Rho guanyl-nucleotide exchange factor activity,epidermal growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VAV3 itself. We selected most functions VAV3 had, and list some proteins which have the same functions with VAV3. You can find most of the proteins on our site.

    Function Related Protein
    guanyl-nucleotide exchange factor activity RASGRP3,GDPGP1,ARHGEF7B,RAPGEF1B,BCAR3,FLCN,ITSN1,RASGRP1,RALGPS2,FAM116B
    Rho guanyl-nucleotide exchange factor activity FGD4,TRIOA,FGD5,PLEKHG6,PLEKHG7,KALRNB,ARHGEF40,ARHGEF39,SOS1,DOCK10
    protein binding MPHOSPH6,OLFM4,TIMP1,AP2S1,ANKZF1,LOC729991,ARIH2,RXFP4,DMD,GAP43
    epidermal growth factor receptor binding SHC1,SOCS5,TGFA,HBEGF,EFEMP1,SNX1,TNK2,RNF126,VAV2,ARF4
    Rac guanyl-nucleotide exchange factor activity ALS2,SPATA13,DOCK2,ARHGEF4,FARP1,VAV1,FARP2,PREX2,ARHGEF2
    metal ion binding ZNF423,ELAC2,SCNM1,ZFPM2,DGCR8,ARHGAP29,TRIM43A,ZNF143A,BRD1B,UGP2

    Interacting Protein

    VAV3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAV3 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAV3.

    VAV3 Related Signal Pathway

    Resources

    References

    • Kwak, SH; Park, YJ; et al. A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans. HUMAN MOLECULAR GENETICS 23:4433-4442(2014).
    • Qi, HY; Wei, L; et al. Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2. INTERNATIONAL JOURNAL OF ONCOLOGY 36:725-735(2010).

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