VAV3

  • Official Full Name

    vav 3 guanine nucleotide exchange factor

  • Overview

    The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels. As a signalling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein. Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response.

  • Synonyms

    VAV3;vav 3 guanine nucleotide exchange factor;vav 3 oncogene;guanine nucleotide exchange factor VAV3;VAV-3;FLJ40431

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cell
  • HEK293
  • Mammalian cells
  • HEK293T
  • His
  • His&Fc&Avi
  • Myc&DDK
  • Flag

    Involved Pathway

    VAV3 involved in several pathways and played different roles in them. We selected most pathways VAV3 participated on our site, such as cAMP signaling pathway,Chemokine signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAV3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Natural killer cell mediated cytotoxicity NFATC2,VAV2,Raet1a,PTPN6,FCGR3B,IFNB1,GM-CSF,PPP3R1,PIK3CD,RAET1L
    T cell receptor signaling pathway CDC42,IKBKB,MAPK12,NFATC3,PPP3R1,RELA,NFKBIB,PAK3,LCK,PDCD1
    Fc epsilon RI signaling pathway FCER1A,VAV1,GAB2,FYN,INPP5D,MAPK10,MAP2K1,NRAS,MAP2K7,HRAS
    cAMP signaling pathway HTR1E,GLI3,CALML5,BDNF,CNGA2,SLC9A1,GLI1,PIK3R5,RHOA,HCN2
    Chemokine signaling pathway WAS,NFKBIA,GSK3B,CCL24,FOXO3,CCL28,Adcy4,PIK3CG,CCL18,ADRBK2
    Leukocyte transendothelial migration GNAI2,NCF1,CD99,CDH5,CLDN2,PXN,PIK3R5,THY1,ICAM1,VAV2
    Focal adhesion VAV1,ILK,ITGB4,AKT3A,MAPK8B,MYLK3,STYK1,ITGA7,COL5A2A,THBS3A
    B Cell Receptor Signaling Pathway MAP2K1,PTPN18,CD79A,PDK2B,MAPK4,RAP2A,CR2,PPP3CB,HDAC5,INPP5D
    Regulation of Actin Cytoskeleton HRASA,ITGA1,PIK3R1,PTK2,PPP1CAA,LIMK2,PIP5K1BB,PIKFYVE,WAS,ITGB5

    Protein Function

    VAV3 has several biochemical functions, for example, Rac guanyl-nucleotide exchange factor activity,Rho guanyl-nucleotide exchange factor activity,epidermal growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VAV3 itself. We selected most functions VAV3 had, and list some proteins which have the same functions with VAV3. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding GNAI1,ARHGAP29,KDM2AA,SP8A,ZFP36L3,DPF2L,ADAP1,ERI1,ZDHHC23B,GALNT14
    Rac guanyl-nucleotide exchange factor activity PREX2,VAV1,ARHGEF4,FARP2,DOCK2,ARHGEF2,SPATA13,FARP1,ALS2
    guanyl-nucleotide exchange factor activity ARHGEF11,DOCK1,TBXA2R,RPGR,RAPGEF6,VAV1,ARHGEF19,RAPGEF3,PREX1,DOCK8
    Rho guanyl-nucleotide exchange factor activity VAV2,ITSN2,FLJ20184,ARHGEF9,FGD4A,TIAM2,ARHGEF16,FARP1,ARHGEF1B,SOS1
    protein binding UVRAG,FAM120B,PKHD1L1,ALDH7A1,PODXL2,HNRNPH3,SLC9A3,CASP9,SLC9A3R2,GRID2IP
    epidermal growth factor receptor binding ERBB4,TGFA,SHC1,GRB2,SNX4,CBLC,Fert2,HBEGFB,PLSCR1,SNX1

    Interacting Protein

    VAV3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAV3 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAV3.

    VAV3 Related Signal Pathway

    Resources

    References

    • Kwak, SH; Park, YJ; et al. A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans. HUMAN MOLECULAR GENETICS 23:4433-4442(2014).
    • Qi, HY; Wei, L; et al. Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2. INTERNATIONAL JOURNAL OF ONCOLOGY 36:725-735(2010).

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