VAPB
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Official Full Name
VAMP (vesicle-associated membrane protein)-associated protein B and C -
Overview
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. -
Synonyms
VAPB;VAMP (vesicle-associated membrane protein)-associated protein B and C;vesicle-associated membrane protein-associated protein B/C;ALS8;VAP B;VAP C;ALS 8;D2Abb2e;UNQ484/PRO983;Vamp 33b;VAMP associated 33 kDa protein;VAMP associated protein B and C;VAMP associated protein B;VAMP associated protein B/C;VAMP associated protein C;VAMP B;VAMP B VAMP C;VAMP B/VAMP C;VAMP C;VAMP vesicle associated membrane protein associated protein B and C;Vamp33b;VAMPB;VAMPB/VAMPC;VAMPC;VAP 33b;VAP B/VAP C;VAP33b;VAPB/VAPC;VAPC;Vesicle associated membrane protein associated protein B and C;Vesicle associated membrane protein associated protein B/C;OTTHUMP00000031393;OTTHUMP00000174286;VAMP-associated 33 kDa protein;VAP-B;VAMP-B
Recombinant Proteins
- Human
- Cynomolgus
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- Bovine
- Sus scrofa (Pig)
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
VAPB involved in several pathways and played different roles in them. We selected most pathways VAPB participated on our site, such as Metabolism,Metabolism of lipids and lipoproteins,Sphingolipid de novo biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAPB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of lipids and lipoproteins | STARD5,ARSK,CYP4F11,PITPNB,MED23,APOBB.1,PTGDSA,AKR1C2,GLTP,TMEM195 |
| Sphingolipid de novo biosynthesis | SGMS2,SPTLC1,COL4A3BP,FA2H,ACER1,PPM1LB,PPM1LA,OSBP,CERS3B,PPM1L |
| Sphingolipid metabolism | SMPD5,ASAH1,ARSE,CERS4,ACER1,SMPD1,B4GALT6,SPHK1,GLTP,SMPD3 |
| Metabolism | ECI1,MTF1,SLC27A2A,NOSTRIN,COX6B1,SLC25A20,COX18,PEMT,MED16,PLD6 |
Protein Function
VAPB has several biochemical functions, for example, FFAT motif binding,beta-tubulin binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VAPB itself. We selected most functions VAPB had, and list some proteins which have the same functions with VAPB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | GCH1,MTMR2,GABPB2,IGJ,SLC26A5,VPS25,FAM109B,Il6ra,IRAK2,NR6A1A |
| protein heterodimerization activity | SEPHS1,BDKRB2,CEBPA,TXLNG,UGT1A2,HIST4H4,H2AFB2,PIK3R2,UBA3,HOMER2 |
| protein binding | RPL15,LIN28B,FBLN1,HSPA1L,MARCH2,SPATA2,RUNX2,EYA3,ZBTB48,WBP11 |
| enzyme binding | GOT2,HSPA6,TSPAN15,HDAC10,GSTM7,CDK19,RPS2,PEBP1,PRMT1,CD40 |
| beta-tubulin binding | UXT,SIRT2,PACRG,SERPINB1A,HDAC6,SNCA,RANBP10,AKAP1,CCT5,ARL8B |
| microtubule binding | GAS2L3,TXNDC3,PRNP,RPS3,MAPRE1B,TERF1,MACF1,TRPV4,CHP,JAKMIP3 |
| FFAT motif binding | VAPAL,VAPA |
Interacting Protein
VAPB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAPB here. Most of them are supplied by our site. Hope this information will be useful for your research of VAPB.
YIF1A;Rmdn3;OSBPL9;Rassf1;VAPA;q03463-pro_0000278740
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