USP9X

  • Official Full Name

    ubiquitin specific peptidase 9, X-linked

  • Overview

    This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

  • Synonyms

    USP9X;ubiquitin specific peptidase 9, X-linked;FAF;FAM;DFFRX;probable ubiquitin carboxyl-terminal hydrolase FAF-X;hFAM;fat facets in mammals;ubiquitin thioesterase FAF-X;deubiquitinating enzyme FAF-X;ubiquitin thiolesterase FAF-X;fat facets protein related, X-linked;fat facets protein-related, X-linked;Drosophila fat facets related, X-linked;ubiquitin-specific protease 9, X chromosome;ubiquitin-specific processing protease FAF-X;ubiquitin-specific-processing protease FAF-X;ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila)

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Sf21 Insect Cell
  • Mammalian Cell
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
USP9X-184H Active Recombinant Human USP9X, GST-tagged E.coli Human GST 1554-1995 a.a.
USP9X-658H Active Recombinant Human USP9X, Met&His-tagged Sf21 Insect Cell Human His
USP9X-17945M Recombinant Mouse USP9X Protein Mammalian Cell Mouse His
USP9X-0343H Recombinant Human USP9X Protein (K1554-N1995), GST tagged E.coli Human GST K1554-N1995
USP9X-0344H Recombinant Human USP9X Protein (K1554-N1995), Tag Free E.coli Human Non K1554-N1995
USP9X-9977M Recombinant Mouse USP9X Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
USP9X-9977M-B Recombinant Mouse USP9X Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    USP9X involved in several pathways and played different roles in them. We selected most pathways USP9X participated on our site, such as Downregulation of SMAD2/3:SMAD4 transcriptional activity,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP9X were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Downregulation of SMAD2/3:SMAD4 transcriptional activity PARP1,SKIB,SKILB,RNF111,SKIA,SMAD3B,SKI,TRIM33,USP9
    Gene Expression CHST13,ZCRB1,ZNF543,ZNF70,PAPOLA,ESRRA,NR6A1A,ZNF496,AARS,ZNF577
    Signaling by TGF-beta Receptor Complex STRAP,PMEPA1,SKIB,SKILB,NEDD8,UCHL5,USP15,CGNB,SKIA,TRIM33
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer SKILB,USP9,TRIM33,SKIB
    Generic Transcription Pathway ZNF485,TXN,ZNF10,NR2F1B,Txn1,NR2F6,ZFP1,ZNF620,JUNB,NKX2
    Signal Transduction CLPS,APOC2,SPRY1,PDK2B,SOX9A,PROK1,MYO7A,CALML4,FSTL3,SOX13

    Protein Function

    USP9X has several biochemical functions, for example, co-SMAD binding,cysteine-type endopeptidase activity,cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP9X itself. We selected most functions USP9X had, and list some proteins which have the same functions with USP9X. You can find most of the proteins on our site.

    Function Related Protein
    co-SMAD binding SMAD6,SMAD1,SMAD2,FOXH1,TGIF1,CITED1,TRIM33,SMAD3,GATA4
    protein binding RAB27A,RAB39B,Car4,SDC1,ABCB1,UQCRB,FOXP3,GOLGA3,CHAC1,VEGFB
    cysteine-type endopeptidase activity USP18,Ctsl,USP20,ATG4A,FMNL3,ESPL1,USP28,USP1,CASPBL,CTSL.1
    ubiquitin-specific protease activity CYLD,FMNL3,ATXN3L,UCHL3,USP24,USP22,USP48,MYSM1,USP17L2,OTUD5
    cysteine-type peptidase activity FAM49BA,CASPC,CTSBB,CAPN3A,CASP7,Casp3,CAPN2,CASP8L1,SENP7,CASP3B

    Interacting Protein

    USP9X has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP9X here. Most of them are supplied by our site. Hope this information will be useful for your research of USP9X.

    NFKB2;NUAK1;MYC;JUN;PHB;CASP4;NFKB2;RELB;MAP3K1;SMAD4;TSC22D1;NEK6;HTT

    Resources

    Research Area

    Deubiquitinating Enzymes (DUBs)

    References

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