USP25
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Official Full Name
ubiquitin specific peptidase 25 -
Overview
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein;breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of;the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999;(PubMed 10644437)). -
Synonyms
USP25;ubiquitin specific peptidase 25;ubiquitin specific protease 25;ubiquitin carboxyl-terminal hydrolase 25;USP21;USP on chromosome 21;ubiquitin thioesterase 25;deubiquitinating enzyme 25;ubiquitin thiolesterase 25;ubiquitin-specific processing
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
USP25 involved in several pathways and played different roles in them. We selected most pathways USP25 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
USP25 has several biochemical functions, for example, ATPase binding,SUMO binding,cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP25 itself. We selected most functions USP25 had, and list some proteins which have the same functions with USP25. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | CUL3,MUL1,USP13,FHIT,DAXX,RRAGA,TRIB1,SPOP,TOLLIP,NDUFS2 |
| protein binding | ANP32B,MKNK2,EPN2,BCL7A,ZNF593,GATA5,PDCD4,MOXD1,FOXP2,MAP3K4 |
| peptidase activity | IMMP2L,CTRC,CAPN2A,MBTPS2,PRSS44,KLK5,DPEP3,IHHA,TMPRSS5,NOTS |
| cysteine-type endopeptidase activity | ATG4C,USP8,UCHL1,USP43A,CTSH,CTS7,USP37,CASP9,CTSL1,BLMH |
| SUMO binding | USPL1,RPS3,CBX4,PML,TDG,TOLLIP,HERC2 |
| ATPase binding | ATP6V0A1,SDF2L1,TAF9,ATP6V0A2B,ATP1B1,ATP6V0A4,BBC3,PTPN3,PIH1D1,Ar |
| ubiquitin binding | UBE2N,SPRTN,SIRT2,UBAP1,OTUB1B,RNF168,DNAJC2,USP13,PARK2,BCL10 |
| ubiquitin-specific protease activity | USP12,USP24,JOSD2,USP19,USP7,USP44,DUB1,OTUD4,USP31,USP3 |
Interacting Protein
USP25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP25 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP25.
SYK;MAGEB4;RAD23A;SUMO2;ZNF426;TNKS2;TRAF5
Resources
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References
- Wang, L; Huang, JX; et al. Adenosylmethionine Decarboxylase 1 (AMD1)-Mediated mRNA Processing and Cell Adhesion Activated & Inhibited Transition Mechanisms by Different Comparisons Between Chimpanzee and Human Left Hemisphere. CELL BIOCHEMISTRY AND BIOPHYSICS 70:279-288(2014).
- Li, J; Tan, Q; et al. miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25. MOLECULAR CANCER 13:-(2014).
