UQCRFS1
-
Official Full Name
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -
Synonyms
LRRGT00195
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Rat
- Symphalangus syndactylus (Siamang) (Hylobates syndactylus)
- Pan paniscus
- Saimiri sciureus (Common squirrel monkey)
- Chlorocebus Aethiops
- Pan troglodytes
- Pongo Pygmaeus
- Gorilla gorilla gorilla (Western lowland gorilla)
- Lagothrix lagotricha (Brown woolly monkey) (Humboldt's woolly monkey)
- Aotus azarae (Southern owl monkey) (Aotus azarai)
- Bovine
- Colobus polykomos (Western black-and-white colobus monkey)
- Mus musculus
- Theropithecus gelada (Gelada baboon)
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli expression system
- E. coli
- E.coli
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
UQCRFS1 involved in several pathways and played different roles in them. We selected most pathways UQCRFS1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with UQCRFS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cardiac muscle contraction | COX7B,COX8A,ATP1B1,SLC8A1,UQCRQ,ATP1B2A,CACNG1,MYH15,CACNG6A,CACNA2D2 |
| Metabolic pathways | SPR,UOX,MLYCD,CHIA.2,ATP6V0A2B,ALG2,LDHAL6A,ADH1B,GALT,NDUFS1 |
| Huntingtons disease | COX7A2L,COX6A2,ATP5H,POLR2B,SLC25A5,NDUFV1,BDNF,NDUFA8,ITPR1,NDUFS7 |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFS1,KCNA3,RELA,NDUFB4,CYCS,INS2,UQCR10,NDUFC2-KCTD14,LEPR,UQCRC2 |
| Alzheimers disease | ATP5O,UQCRB,MAPT,ATP5D,NDUFS6,BACE1,APBB1,RYR3,SNCA,NDUFS1 |
| Parkinsons disease | PRKACB,NDUFB1,NDUFA9,NDUFA11,UQCRB,SDHB,NDUFA13,PARK7,ATP5F1,NDUFB10 |
| Oxidative phosphorylation | ATP6V0B,NDUFS3,ATP6V1G2,ATP5IB,Atp5k,NDUFA6,UQCR11,ATP5I,ATP6V1BA,UQCRC1 |
Protein Function
UQCRFS1 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding,metal ion binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UQCRFS1 itself. We selected most functions UQCRFS1 had, and list some proteins which have the same functions with UQCRFS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquinol-cytochrome-c reductase activity | UQCRH,UQCR10,UQCRC1,UQCR11,UQCRQ |
| 2 iron, 2 sulfur cluster binding | AOX3L1,FDX1L,FXN,AOX4,AOX3,NDUFS1,ISCA1,AOX1,RFESD,ISCA2 |
| metal ion binding | RSAD1,GLIS3,UGP2,ZFP13,ZNF507,CHD4A,ATP2B4,UNC13A,ZFP628,ACVRL1 |
| protein complex binding | KIF11,PTK2B,PDCL,Casp3,Apba1,BAX,ST13,ULK1,FGFR1,NDUFA4 |
Interacting Protein
UQCRFS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UQCRFS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UQCRFS1.
UQCRC1;VHL;SOX5;RELB;NDUFS5;MYC;COX6C;Rab5c;ICT1;NDUFA9;Rmdn3;NDUFA11;NDUFA13;VAPA;NDUFA12;GOLT1B
Resources
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References
- Dato, S; Soerensen, M; et al. Contribution of genetic polymorphisms on functional status at very old age: A gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. EXPERIMENTAL GERONTOLOGY 52:23-29(2014).
- Sanchez, E; Lobo, T; et al. LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of mitochondrial Complex III assembly in human cells. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1827:285-293(2013).
