UPF1
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Official Full Name
UPF1 regulator of nonsense transcripts homolog (yeast) -
Overview
Upf1 is a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. In mammalian cells NMD generally requires that translation terminates upstream of a post-splicing exon junction complex (EJC). The subsequent binding of Upf1 to the EJC triggers Upf1 phosphorylation. Data suggests that phospho-Upf1 interacts directly with eif3 and inhibits the eif3-dependent conversion of 40S ribosome complex to translationally competent 80S ribosome initiation complex to repress continued translation initiation. -
Synonyms
UPF1;UPF1 regulator of nonsense transcripts homolog (yeast);regulator of nonsense transcripts 1 , RENT1;regulator of nonsense transcripts 1;HUPF1;KIAA0221;NORF1;pNORF1;smg 2;smg 2 homolog;nonsense mediated mRNA decay factor (C. elegans);UP Frameshift 1;delta helicase;yeast Upf1p homolog;ATP-dependent helicase RENT1;nonsense mRNA reducing factor 1;up-frameshift mutation 1 homolog;up-frameshift suppressor 1 homolog;smg-2 homolog, nonsense mediated mRNA decay factor;RENT1;smg-2;FLJ43809;FLJ46894
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Mammalian cells
- HEK293
- HEK293T
- GST
- His
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
UPF1 involved in several pathways and played different roles in them. We selected most pathways UPF1 participated on our site, such as RNA transport,mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with UPF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | PPP2R5CB,MAGOH,ETF1,PAPOLB,GSPT1,PPP1CAA,SRRM1,MSI1,PABPC5,UPF3A |
| RNA transport | RPP38,PNN,PEAK1,NUP62L,EIF3JB,NUP153,EIF3H,NUP160,SNUPN,PABPC1 |
Protein Function
UPF1 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UPF1 itself. We selected most functions UPF1 had, and list some proteins which have the same functions with UPF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | GTF2I,MXTX2,ZNF823,ZFP146,IRX7,HIST1H2BL,HOXC5A,ZNF490,GM14478,THAP5 |
| ATP binding | SMC3,DDX17,P2RX5,KIF5C,LACE1,BMPR2A,DARS,RUNX3,VWA8,NRK |
| ATP-dependent RNA helicase activity | DDX19,DDX5,DDX42,DHX8,DDX18,DDX55,DDX51,DDX49,DDX59,SKIV2L |
| protein binding | Siglec1,PEX19,AURKA,LTBP1,RAN,SERPINA1A,LMF2,C8orf33,RRAGA,ZBTB5 |
| zinc ion binding | TGFB1I1,ZDHHC11,PPARD,DMD,RNF2,LMO7B,SLC30A7,NR2F5,RORAA,ZSWIM4 |
| poly(A) RNA binding | FASTKD3,GM5506,PPIB,RPS9,SRSF1,EBNA1BP2,DHX37,RPS11,RBM4B,RPL5 |
| helicase activity | HELQ,RTEL1,EIF4A1A,RAD54L,ACTG2,MCM6L,EIF4A1B,MOV10B.2,ZRANB3,HLTF |
| chromatin binding | SETD7,NFATC3,DNAJC2,TAL1,MEOX1,LRWD1,NFKB2,AAAS,ESR1,TOX4 |
| RNA binding | NUFIP2,CRNKL1,RPL34,CELF5,LIN28A,PUF60B,RBM46,CWC22,NUFIP1,RPS3A |
Interacting Protein
UPF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UPF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UPF1.
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