UNC13D
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Official Full Name
unc-13 homolog D -
Overview
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. -
Synonyms
UNC13D;unc-13 homolog D (C. elegans);protein unc-13 homolog D;Munc13 4;FHL3;HLH3;HPLH3;Munc13-4
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UNC13D-17843M | Recombinant Mouse UNC13D Protein | Mammalian Cell | Mouse | His |
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| UNC13D-28544TH | Recombinant Human UNC13D, His-tagged | E.coli | Human | His | 861-1090 a.a. |
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| UNC13D-6447R | Recombinant Rat UNC13D Protein | Mammalian Cell | Rat | His |
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| UNC13D-501HCL | Recombinant Human UNC13D 293 Cell Lysate | HEK293 | Human | Non |
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| UNC13D-285H | Recombinant Human UNC13D protein, His-tagged | E.coli | Human | His | 1-327 aa |
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| UNC13D-6103R | Recombinant Rat UNC13D Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| UNC13D-6103R-B | Recombinant Rat UNC13D Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| UNC13D-6204H | Recombinant Human UNC13D Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Unc13d-6836M | Recombinant Mouse Unc13d Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| UNC13D-9912M | Recombinant Mouse UNC13D Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| UNC13D-9912M-B | Recombinant Mouse UNC13D Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
UNC13D involved in several pathways and played different roles in them. We selected most pathways UNC13D participated on our site, such as Deregulation of Rab and Rab Effector Genes in Bladder Cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Deregulation of Rab and Rab Effector Genes in Bladder Cancer | SYTL3,SYTL2,SYTL4,GCC2,RAB27A,SYTL1,RPH3A,TBC1D10A,EXPH5,MYRIP |
Protein Function
UNC13D has several biochemical functions, for example, Rab GTPase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13D itself. We selected most functions UNC13D had, and list some proteins which have the same functions with UNC13D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rab GTPase binding | EVI5L,ANKRD27,CCDC64,CFAP45,SYTL2,MICALL2,USP6NL,DENND5A,SYTL3,RABGGTA |
| protein binding | P4HA1,SEC24D,FAM21C,OSTB,RIPPLY1,GALR2,CITED1,CD160,MID2,HSPB6 |
Interacting Protein
UNC13D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC13D here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC13D.
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