UBE4A

  • Official Full Name

    ubiquitination factor E4A

  • Overview

    This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohns disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

  • Synonyms

    UBE4A;ubiquitination factor E4A;ubiquitination factor E4A (homologous to yeast UFD2) , ubiquitination factor E4A (UFD2 homolog, yeast);ubiquitin conjugation factor E4 A;E4;KIAA0126;UBOX2;UFD2;ubiquitination factor E4A (UFD2 homolog, yeast);MGC13

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
UBE4A-3551H Recombinant Human UBE4A, His-tagged E.coli Human His C-350aa
UBE4A-17741M Recombinant Mouse UBE4A Protein Mammalian Cells Mouse His
UBE4A-2599C Recombinant Chicken UBE4A Mammalian Cells Chicken His
UBE4A-6406R Recombinant Rat UBE4A Protein Mammalian Cells Rat His
UBE4A-480H Recombinant Human UBE4A Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
UBE4A-6028H Recombinant Human UBE4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
UBE4A-6062R Recombinant Rat UBE4A Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
UBE4A-6062R-B Recombinant Rat UBE4A Protein Pre-coupled Magnetic Beads HEK293 Rat
UBE4A-9844M Recombinant Mouse UBE4A Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
UBE4A-9844M-B Recombinant Mouse UBE4A Protein Pre-coupled Magnetic Beads HEK293 Mouse
Ube4a-997M Recombinant Mouse Ube4a Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    UBE4A involved in several pathways and played different roles in them. We selected most pathways UBE4A participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis NEDD4L,PIAS4,TRIM32,UBE2A,FBXW11,TCEB2,KEAP1B,MGRN1B,UBE2Q1,COP1

    Protein Function

    UBE4A has several biochemical functions, for example, GTPase inhibitor activity,Roundabout binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE4A itself. We selected most functions UBE4A had, and list some proteins which have the same functions with UBE4A. You can find most of the proteins on our site.

    Function Related Protein
    protein homodimerization activity VOX,TENM1,GRM6,NPPC,CREB3,AADAT,MYPOP,ASNS,CDH13,NR2F2
    calcium ion binding S100A9,CDH18A,PCDH21,CALR3B,CAPN11,MYL5,EFHB,NECAB3,F9A,PCDH2AA1
    Roundabout binding SLIT1B,SLIT1,SLIT1A,SLIT3,GM4980,SLIT2,TGFB1I1
    laminin-1 binding NTN4,DAG1,NID1,LACRT,Shh,SLIT2
    protein binding EPAS1,RARRES2,PRPSAP1,HER11,EIF4EBP3L,FZD3,RB1CC1,AXIN2,HGF,CTDSP1
    heparin binding COMP,SLIT1B,FGF10,CTGFB,APOA5,LIPH,FGF14,SOST,ZNF146,APOB
    heparan sulfate proteoglycan binding AGRN,FST,HRG,GPC4,HPSE2,AZU1,SLIT2,GPC1A,GPC5,GPC1B
    identical protein binding AMELX,SRPX2,CPT1A,MRAP2,USP2,NUDT16,BIN1,PRMT1,DAAM1,KCNH2
    GTPase inhibitor activity CDC42SE1,SLIT2,PDE6D,GPS2,RTKN,IPO5,CPEB2,TNK2,GPS1,ARL2

    Interacting Protein

    UBE4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE4A here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE4A.

    MAVS;PTP4A3;UBE2D1;UBE2D3;UBE2D2;UBE2D4;CBX7

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