UBE4A
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Official Full Name
ubiquitination factor E4A
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Overview
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohns disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
UBE4A; ubiquitination factor E4A; ubiquitination factor E4A (homologous to yeast UFD2) , ubiquitination factor E4A (UFD2 homolog, yeast); ubiquitin conjugation factor E4 A; E4; KIAA0126; UBOX2; UFD2; ubiquitination factor E4A (UFD2 homolog, yeast); MGC13;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- Fc
- Avi
- Myc
- DDK
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | UBE4A-3551H | Recombinant Human UBE4A, His-tagged | E.coli | His | C-350aa | |
| Human | UBE4A-480H | Recombinant Human UBE4A Protein, MYC/DDK-tagged | HEK293 | Myc&DDK |
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| Human | UBE4A-6028H | Recombinant Human UBE4A Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc&DDK |
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| Mouse | UBE4A-17741M | Recombinant Mouse UBE4A Protein | Mammalian Cell | His |
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| Mouse | UBE4A-9844M | Recombinant Mouse UBE4A Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Mouse | Ube4a-997M | Recombinant Mouse Ube4a Protein, MYC/DDK-tagged | HEK293T | Myc&DDK |
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| Mouse | UBE4A-9844M-B | Recombinant Mouse UBE4A Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | UBE4A-6406R | Recombinant Rat UBE4A Protein | Mammalian Cell | His |
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| Rat | UBE4A-6062R | Recombinant Rat UBE4A Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | UBE4A-6062R-B | Recombinant Rat UBE4A Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | UBE4A-2599C | Recombinant Chicken UBE4A | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
UBE4A involved in several pathways and played different roles in them. We selected most pathways UBE4A participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | ANAPC4;NHLRC1;PIAS4B;UBE2D2A;CUL1;UBE2G2;KLHL9;KEAP1B;HERC2 |
UBE4A has several biochemical functions, for example, GTPase inhibitor activity, Roundabout binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE4A itself. We selected most functions UBE4A had, and list some proteins which have the same functions with UBE4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase inhibitor activity | GPS2;RTKN;GPS1;TNK2;UBE4A;CPEB2;ARL2;IPO5;CDC42SE1 |
| Roundabout binding | SLIT1A;TGFB1I1;SLIT2;SLIT1B;SLIT3;GM4980;SLIT1;UBE4A |
| calcium ion binding | CRELD2;EFHB;EFCAB1;CIB1;PCDHGA2;CDH16;SYT7;S100A11;CHP1 |
| chemorepellent activity | SEMA6A;SEMA3BL;EPHA7;FLRT3;SEMA4A;SEMA3AB;SEMA4C;SEMA3AA;SEMA3B |
| heparan sulfate proteoglycan binding | FST;GPC1B;AZU1;HPSE2;GPC1;CFH;UBE4A;SLIT2;HRG |
| heparin binding | PTN;FGF7;CCL8;SERPINE2;SERPINA10;CCDC80;MDK;Itgam&Itgb2;SLIT3 |
| identical protein binding | TRP53;BAX;PHYKPL;CD28;CDC42BPA;GCG;MPST;SYP;TNPO3 |
| laminin-1 binding | DAG1;NTN4;NID1;LACRT;SLIT2;UBE4A;Shh |
| protein binding | PTPRE;CLK4;SNCAIP;GOLM1;IL17RA;ASNS;MNDA;SCRN2;COL1A2 |
| protein homodimerization activity | NAGA;CARS;TLR13;TYR;GDNFA;NUDT16;TGFB2;NCR3;TRPM8 |
| proteoglycan binding | COL5A1;CTSS;CECR1;UBE4A;NID1;THBS1;CTSB;FCN2;CTSL1 |
UBE4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE4A here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE4A.
MAVS; PTP4A3; UBE2D1; UBE2D3; UBE2D2; UBE2D4; CBX7
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