UBE2E3

  • Official Full Name

    ubiquitin-conjugating enzyme E2E 3

  • Overview

    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

  • Synonyms

    UBE2E3;ubiquitin-conjugating enzyme E2E 3;ubiquitin conjugating enzyme E2E 3 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2E 3 (UBC4/5 homolog, yeast);ubiquitin-conjugating enzyme E2 E3;UbcH9;ubiquitin-protein ligase E3;ubiquitin ca

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Rhesus macaque
  • E.coli
  • Mammalian Cell
  • HEK293
  • Insect Cell
  • GST
  • His
  • Non
  • His&Strep
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
UBE2E3-3532H Recombinant Human UBE2E3, GST-tagged E.coli Human GST 1-207aa
UBE2E3-647H Active Recombinant Human UBE2E3 Protein, His-tagged E.coli Human His
UBE2E3-11162Z Recombinant Zebrafish UBE2E3 Mammalian Cell Zebrafish His
UBE2E3-112H Recombinant Human UBE2E3, His-tagged E.coli Human His
UBE2E3-31658TH Recombinant Human UBE2E3 Human Non Full L.
UBE2E3-4135C Recombinant Chicken UBE2E3 Mammalian Cell Chicken His
UBE2E3-5058R Recombinant Rhesus monkey UBE2E3 Protein, His-tagged Mammalian Cell Rhesus macaque His
UBE2E3-580HCL Recombinant Human UBE2E3 293 Cell Lysate HEK293 Human Non
UBE2E3-581HCL Recombinant Human UBE2E3 293 Cell Lysate HEK293 Human Non
UBE2E3-0027H Recombinant Human UBE2E3 Protein (S2-T207), Tag Free Insect Cell Human Non S2-T207
UBE2E3-0028H Recombinant Human UBE2E3 Protein (S2-T207), His/Strep tagged Insect Cell Human His&Strep S2-T207
UBE2E3-4871R Recombinant Rhesus Macaque UBE2E3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
UBE2E3-4871R-B Recombinant Rhesus Macaque UBE2E3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    UBE2E3 involved in several pathways and played different roles in them. We selected most pathways UBE2E3 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2E3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis CUL3,RHOBTB2,SYVN1,RHOBTB1,NEDD4L,UBE2I,BIRC2,MGRN1,UBE3A,UBE2G1B
    protein ubiquitylation RNF216,UEVLD,UBA5,UBE2U
    Adaptive Immune System ASB9,RNF123,TPP2,AMICA1,SEC61B,FCGR1B,UBE2U,SIGLEC8,ARF1,GRAP2A
    Proteasome degradation UBR2,LRSAM1,KLHL20,UCHL3,UBE2V2,ATG7,IWS1,ASB3,UBE2J2,STUB1
    Class I MHC mediated antigen processing &amp CTSL1,ASB18,KLHL21,RNF144B,UBE2U,UBE2F,HUWE1,KLHL20,PJA2,ASB7
    Antigen processing: Ubiquitination &amp ASB8,UBE2J2,TRIM50,FBXO44,RNF6,UBE2F,SPSB2,ASB13,TRIM69,SPSB1
    presentation UBE2V1,SEC61B,TPP2,RNF123,ARIH2,FBXO17,RNF41,TRIM39,PJA1,HECTD3
    Protein processing in endoplasmic reticulum CALR3B,PDIP5,PDIA4,SEL1L2,NFE2L2,DNAJC5B,MBTPS2,UGGT1,SEC63,UBQLN1
    Immune System LILRB1,TAX1BP1B,CD226,RNF14,DEFA5,AGER,DEFB4A,PJA1,CD300LB,WIPF3

    Protein Function

    UBE2E3 has several biochemical functions, for example, ATP binding,protein binding,ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2E3 itself. We selected most functions UBE2E3 had, and list some proteins which have the same functions with UBE2E3. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin conjugating enzyme activity UBE2N,UBE2S,UBE2A,UBE2H,UBE2R2,UBE2B,CDC34,UBE2J2,UBE2Q1,UBE2D2
    ATP binding ATAD1B,LACE1,PAK7,PRKACG,MAPK12B,ABCF2A,RENBP,OXSR1,PMVK,ERBB3A
    ubiquitin-protein transferase activity ZNF738,FBXL14,FBXO4,TRIM37,MARCH2,LTN1,ARIH1,LMO7,MARCH8,BRCA1
    protein binding ROPN1,AIM2,PDIA6,CLOCK,SEC23B,HIST1H4H,GUCY2C,FHIT,GDF5,TCTN2

    Interacting Protein

    UBE2E3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2E3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2E3.

    RNF5;MID1;RNF185;TRIM39;RNF111;RNF25

    Resources

    Research Area

    Parkinson's Disease Related Molecules
    E2 Ubiquitin/Ubl Conjugating Enzymes

    References

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