U2AF2
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Official Full Name
U2 small nuclear RNA auxiliary factor 2 -
Overview
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008] -
Synonyms
U2AF2;U2 small nuclear RNA auxiliary factor 2;U2AF65;splicing factor U2AF 65 kDa subunit;hU2AF65;U2 auxiliary factor 65 kDa subunit;U2 snRNP auxiliary factor large subunit;U2 (RNU2) small nuclear RNA auxiliary factor 2;U2 small nuclear ribonucleoprotein auxiliary factor (65kD)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| U2AF2-3513H | Recombinant Human U2AF2 protein, GST-tagged | E.coli | Human | GST | 116-471 aa | |
| U2AF2-17682M | Recombinant Mouse U2AF2 Protein | Mammalian Cells | Mouse | His |
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| U2AF2-718HCL | Recombinant Human U2AF2 lysate | HEK293 | Human | Non |
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| U2AF2-13H | Recombinant Human U2AF2 Protein (141 a.a.-240 a.a.), N-GST-tagged | Wheat Germ | Human | GST | 141-240 |
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| U2AF2-9806M | Recombinant Mouse U2AF2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| U2AF2-9806M-B | Recombinant Mouse U2AF2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
U2AF2 involved in several pathways and played different roles in them. We selected most pathways U2AF2 participated on our site, such as Cleavage of Growing Transcript in the Termination Region,Gene Expression,Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with U2AF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | DHX38,DDX39B,EFTUD2,SF3B6,DDX46,U2SURP,DDX5,SLU7,PQBP1,PRPF8 |
| RNA Polymerase II Transcription | SRSF11,GM3258,PAPOLA,LSM10,CSTF2,NELFE,NUDT21,CCNT2B,CSTF1,SUPT16H |
| Transport of Mature Transcript to Cytoplasm | SRSF11,SFRS3A,NXF1,SLBP |
| Cleavage of Growing Transcript in the Termination Region | CLP1,CSTF3,RNPS1,LSM10,PAPOLA,ZFP473,SRSF11,ZNF473,LSM11,CSTF1 |
| Gene Expression | ZNF264,MANEA,COX4I1,SNAPC1,ZNF41,ZNF705A,TNPO1,ZNF143,WTAP,ZNF486 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | SRSF11,SFRS3A |
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPH2,SF3A1,HNRNPA0A,HNRNPF,METTL3,HNRPL,CCAR1,PTBP1A,HNRNPL2,CSTF1 |
| RNA Polymerase II Transcription Termination | PAPOLA,RNPS1,THOC4,ZNF473,SLBP,CSTF3,LSM11,CSTF2,ZFP473,LSM10 |
Protein Function
U2AF2 has several biochemical functions, for example, C2H2 zinc finger domain binding,enzyme binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by U2AF2 itself. We selected most functions U2AF2 had, and list some proteins which have the same functions with U2AF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | RXRA,ZNF346,BACE1,KMT2E,CPSF1,YES1,HMOX1,NPM2,POR,KIAA1967 |
| C2H2 zinc finger domain binding | LEF1,HMGA2,EHMT1,WT1,TAF9,EHMT2,ZXDC,THAP7,GATA1,EBF1 |
| poly-pyrimidine tract binding | CPEB2,PTBP1 |
| poly(A) RNA binding | FNDC3B,PES1,SRP19,ALKBH5,CLTC,LRRC59,POLRMT,WDR46,MRPS35,PCBP2 |
| protein binding | GP9,FBF1,FAM117B,CTAG1A,ASB2,C1QTNF9,PRKAB2,SEMG1,NF1,AGPAT5 |
| pre-mRNA 3-splice site binding | ZRSR2,SLU7 |
| nucleotide binding | NLRP4E,AKT3A,FUS,BLM,PUF60,RAB14L,RAB32A,SEPT7B,ABCA13,RBMY1B |
Interacting Protein
U2AF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with U2AF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of U2AF2.
U2AF1;PUF60;SF1
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