Tyrosine Hydroxylase
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Official Full Name
tyrosine hydroxylase -
Overview
Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It does so using molecular oxygen (O2), as well as iron (Fe2+) and tetrahydrobiopterin as cofactors. L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral symphatic neurons and the adrenal medulla. Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs). -
Synonyms
tyrosine hydroxylase
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Involved Pathway
Tyrosine Hydroxylase involved in several pathways and played different roles in them. We selected most pathways Tyrosine Hydroxylase participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Tyrosine Hydroxylase were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
Tyrosine Hydroxylase has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Tyrosine Hydroxylase itself. We selected most functions Tyrosine Hydroxylase had, and list some proteins which have the same functions with Tyrosine Hydroxylase. You can find most of the proteins on our site.
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Interacting Protein
Tyrosine Hydroxylase has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tyrosine Hydroxylase here. Most of them are supplied by our site. Hope this information will be useful for your research of Tyrosine Hydroxylase.
Resources
Research Area
Neurotransmitter Associated EnzymesParkinson's Disease Related Molecules
Neuronal Lineage Markers
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References
- Kiriyama, K; Ohtaki, H; et al. A Nucleoprotein-Enriched Diet Suppresses Dopaminergic Neuronal Cell Loss and Motor Deficit in Mice with MPTP-Induced Parkinson's Disease. JOURNAL OF MOLECULAR NEUROSCIENCE 55:803-811(2015).
- Shelkar, GP; Kale, AD; et al. Alpha-melanocyte stimulating hormone modulates ethanol self-administration in posterior ventral tegmental area through melanocortin-4 receptors. ADDICTION BIOLOGY 20:302-315(2015).
