TYROBP
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Official Full Name
Tyro protein tyrosine kinase binding protein -
Overview
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
TYROBP;Tyro protein tyrosine kinase binding protein;TYRO protein tyrosine kinase-binding protein;DAP12;DNAX-activation protein 12;killer cell activating receptor-associated protein;Karap
Recombinant Proteins
- Mouse
- Rhesus macaque
- Zebrafish
- Rat
- Human
- Mus musculus
- Pan troglodytes
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Flag
- Avi&Fc&His
- DDK&Myc
- GST&His
- His&SUMO
Involved Pathway
TYROBP involved in several pathways and played different roles in them. We selected most pathways TYROBP participated on our site, such as Osteoclast differentiation,Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYROBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Natural killer cell mediated cytotoxicity | Fasl,FCGR3B,HCST,ARAF,H60a,FASLG,KIR2DS3,HLA-G,ITGB2L,GM-CSF |
| Osteoclast differentiation | FCGR1,FCGR4,PIK3CB,FHL2,LCK,LILRA1,TGFB1,BLNK,NOX3,NFATC2 |
Protein Function
TYROBP has several biochemical functions, for example, identical protein binding,protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TYROBP itself. We selected most functions TYROBP had, and list some proteins which have the same functions with TYROBP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | NRG2B,RSPO3,MSN,P2RX7,CD70,NTF7,HSD17B4,IFNL3,FGG,LTB |
| receptor signaling protein activity | BAG4,BAG1,DAXX,RGS12B,CD19,FCAR,FLRT2,ARAF,ADCYAP1,FLRT3 |
| identical protein binding | CASP6,CST3,ERN1,C14orf166,SP100,CLDN17,SSNA1,ALDOA,PRDX1,RGMB |
| protein binding | TUBGCP2,TUB,GEMIN7,UBE2D3,TBX3,TRIM9,PSPC1,TWIST1,TOMM20,RALBP1 |
Interacting Protein
TYROBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYROBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TYROBP.
KLRC2;SIRPB1;SYK;SIGLEC14;KIR2DS3;purL;gmhB;astD
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