Txn1
-
Official Full Name
thioredoxin 1 -
Overview
Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes. In humans, it is encoded by the TXN gene. Loss-of-function mutation of either of the two human thioredoxin genes is lethal at the four-cell stage of the developing embryo. Although not entirely understood, thioredoxin plays a central role in humans and is increasingly linked to medicine through their response to reactive oxygen species (ROS). In plants, thioredoxins perform a spectrum of critical functions, ranging from photosynthesis to growth, flowering and the development and germination of seeds. It has also recently been found to play a role in cell-to-cell communication. -
Synonyms
Txn1;ADF;Txn;Trx1;AW550880;thioredoxin 1;thioredoxin;trx;ATL-derived factor;trxA;dasC;ECK3773;fip;fipA;JW5856;tsnC
Recombinant Proteins
- Mouse
- Bacillus subtilis
- E.coli
- Rat
- Helicobacter pylori
- Helicobacter Pylori
- Shigella flexneri
- E.coli
- E.Coli/Yeast
- Mammalian Cells
- HEK293
- Non
- His
- Avi
- Fc
- DDK
- Myc
Involved Pathway
Txn1 involved in several pathways and played different roles in them. We selected most pathways Txn1 participated on our site, such as Cellular Senescence,Cellular responses to stress,Detoxification of Reactive Oxygen Species, which may be useful for your reference. Also, other proteins which involved in the same pathway with Txn1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Innate Immune System | NLRP4C,DEFB121,SIGIRR,PPAPDC1B,NLRP4E,TREX1,CD300LB,BTR30,DEFB103A,MYO1C |
| Cellular Senescence | TINF2,TERF2IP,HIST3H2BB,AGO3,HMGA1B,CDK6,KDM6B,HIST4H4,E2F3,CBX4 |
| Detoxification of Reactive Oxygen Species | TXNRD2,TXN2,TXN,PRDX3,PRDX2 |
| Generic Transcription Pathway | ZNF227,GPR19,NR5A1,SKIA,NR2E1,ZNF529,NR1I2,ZFP90,ZNF697,PSTPIP2 |
| Gene Expression | AGO3B,NR2F1,COX14,SNRNP35,EARS2,ASZ1,MBD3B,PTBP1B,POU2F1B,ZNF599 |
| Inflammasomes | BTR16,NLRP3,BTR30,BTR18,SUGT1,PANX1A,PANX1B,BTR12,BTR06,TXNIPB |
| Immune System | IFI30,EIF4G2A,LRR1,KLRB1B,UFL1,RBCK1,SPSB1,KLRF1,FCN1,OSCAR |
| Cellular responses to stress | TXNRD2,ASF1A,AMBRA1,ATG9A,HTATIP,H3F3B.1,H3F3D,PTGES3,HSPA13,SUZ12B |
Protein Function
Txn1 has several biochemical functions, for example, enzyme binding,peptide disulfide oxidoreductase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Txn1 itself. We selected most functions Txn1 had, and list some proteins which have the same functions with Txn1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide disulfide oxidoreductase activity | TXNDC12,TXN |
| enzyme binding | PLCE1,GSTM1,BLZF1,PRKCH,TRIO,KIAA1967,KRT79,RARA,ECM1,CSF3 |
| poly(A) RNA binding | MRPS23,MTIF2,RBMX,RBM12B2,MRPS24,EXOSC6,RALY,UBE2L3,DHX36,G3BP2 |
| protein binding | SSX3,CARD11,ACTR6,KLK4,REXO1L1,SIRPB1,MAPRE1,PLEKHG6,COMMD6,PCBD2 |
Interacting Protein
Txn1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Txn1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Txn1.
Ywhae;Dlg4;Pgls
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