TUBA1B
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Official Full Name
tubulin, alpha 1b -
Overview
Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. The building block of a microtubule is the tubulin subunit, a heterodimer of alpha and beta-tubulin. Both of these monomers are found in all eukaryotes, and their sequences are highly conserved. Acetylated alpha tubulin is present in various microtubule structures and plays a role in stabilizing the structures of all microtubules. -
Synonyms
TUBA1B;tubulin, alpha 1b;K-ALPHA-1;tubulin alpha-1B chain;alpha tubulin;tubulin K-alpha-1;alpha-tubulin ubiquitous;tubulin, alpha, ubiquitous;tubulin alpha-ubiquitous chain;Acetylated alpha tubulin
Recombinant Proteins
- Cynomolgus
- Mouse
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mammalian Cells
- HEK293
- Wheat Germ
- E.coli
- In Vitro Cell Free System
- His
- Myc&DDK
- Non
- N-His
- His&Fc&Avi
- Flag
Involved Pathway
TUBA1B involved in several pathways and played different roles in them. We selected most pathways TUBA1B participated on our site, such as Chaperonin-mediated protein folding,Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding,Formation of tubulin folding intermediates by CCT/TriC, which may be useful for your reference. Also, other proteins which involved in the same pathway with TUBA1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Formation of tubulin folding intermediates by CCT/TriC | TUBB4A,CCT6A,TCP1,CCT7,CCT5,TUBA3D,CCT4,TUBB4B,CCT8,CCT3 |
| Parkin-Ubiquitin Proteasomal System pathway | STUB1,TUBB7P,HSPA14,UBE2J2,TUBA3D,RNF19A,TUBA3E,SIAH2,HSPA7 |
| Phagosome | ATPV0E2,FCGR3B,C1RA,ATP6V1F,CTSSB.2,DYNC1I1,CD209C,ATP6V0C,ITGB3B,BF1 |
| Pathogenic Escherichia coli infection | TUBA8,CD14,OCLN,KRT18,NCK2,ACTG1,FYN,TUBB2A,ITGB1,LY96 |
| Metabolism of proteins | PAPPA2,FBXW4,TRAPPC4,GCNT3,TRAPPC3,TIMM44,PFDN5,ADAMTS4,GRPEL1,CALCA |
| Chaperonin-mediated protein folding | NOP56,CCT8,CCT4,PFDN4,PFDN2,TUBA3D,CCT5,FBXW2,TCP1,PFDN5 |
| Gap junction | TUBA4L,CDK1,MAPK1,ADRB3B,TUBB2,PDGFAB,PRKCG,TUBA1L2,HTR2B,TUBA8L3 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | CCT8,PFDN6,CCT6A,CCT7,TCP1,CCT3,CCT5,TUBB4B,PFDN4,CCT2 |
Protein Function
TUBA1B has several biochemical functions, for example, GTP binding,GTPase activity,double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TUBA1B itself. We selected most functions TUBA1B had, and list some proteins which have the same functions with TUBA1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural molecule activity | KRTAP3-3,CRCT1,DESMB,ANK1,NGS,EPB41L1,SNTG2,LELP1,DESMA,NEFH |
| GTP binding | GNAI3,ARL3L2,HRASB,GNA11A,OLA1,HRASA,RAB22A,RAB43,ARL8,RAB13 |
| structural constituent of cytoskeleton | VIM,EPB42,NEFH,ACTL6B,KRT17,TUBD1,ANK1,MSN,TUBA1C,ADD3 |
| ubiquitin protein ligase binding | PRKAR2A,TNFRSF1B,CD40,UBE2V1,AKTIP,CASP8,AURKA,MAP1LC3B,TP53,TCP1 |
| double-stranded RNA binding | AGO1,DHX36,EIF2AK2,APTX,EIF4A1,ILF2,STAU1,TLR8,RNASEN,OAS1 |
| GTPase activity | DDX3X,ATL3,RHOD,RAB31,TUBE1,EEF1A1L1,GNG3,GNGT1,RAB25A,MFN1B |
| protein binding | ASGR1,EFCAB4A,TJAP1,PDCD2,TEF,FOXC1,CRIPT,C19orf46,TXNL4B,RNASEL |
Interacting Protein
TUBA1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TUBA1B here. Most of them are supplied by our site. Hope this information will be useful for your research of TUBA1B.
TUBB3;AGTRAP;EBNA-LP;YWHAZ;SMAD2;TOM1L1;TMEM253;SLX1A;STARD13;bosutinib;imatinib;dasatinib;midostaurin
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References
- Groh, KJ; Schonenberger, R; et al. Analysis of protein expression in zebrafish during gonad differentiation by targeted proteomics. GENERAL AND COMPARATIVE ENDOCRINOLOGY 193:210-220(2013).
- Lu, CH; Zhang, J; et al. Increased alpha-Tubulin1b Expression Indicates Poor Prognosis and Resistance to Chemotherapy in Hepatocellular Carcinoma. DIGESTIVE DISEASES AND SCIENCES 58:2713-2720(2013).
