TTBK2
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Official Full Name
tau tubulin kinase 2 -
Overview
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this;gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and;atrophy of the cerebellum and brainstem. -
Synonyms
TTBK2;tau tubulin kinase 2;SCA11, spinocerebellar ataxia 11;tau-tubulin kinase 2;KIAA0847;SCA11;Spinocerebellar ataxia 11;TTBK;TTBK 2;TTBK2_HUMAN
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TTBK2-3512H | Recombinant Human TTBK2 protein, His-tagged | E.coli | Human | His | 1-354 aa | |
| TTBK2-1502M |
Active Recombinant Mouse TTBK2, GST-tagged
|
Sf9 Cells | Mouse | GST | 70-538 aa |
|
| TTBK2-1114H | Recombinant Human Tau Tubulin Kinase 2, GST-tagged | Sf9 Cells | Human | GST | 70-538 a.a. |
|
| TTBK2-1312H | Recombinant Human TTBK2 protein, His & GST-tagged | E.coli | Human | GST&His | Trp21~Thr314 |
|
| TTBK2-1850HCL | Recombinant Human TTBK2 cell lysate | Human | Non |
|
||
| TTBK2-4568H | Recombinant Human TTBK2 protein, His&Myc-tagged | E.coli | Human | His&Myc | 18-287aa |
|
Involved Pathway
TTBK2 involved in several pathways and played different roles in them. We selected most pathways TTBK2 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTBK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of the primary cilium | CCT2,KIF3A,BBS2,KIF3B,KIFAP3B,ODF2,TCTN1,IFT80,DYNLRB1,DCTN1 |
| Anchoring of the basal body to the plasma membrane | CEP78,CEP97,MAPRE1A,CCDC41,CSNK1E,CEP152,CEP63,FBF1,OFD1,PLK4 |
| Organelle biogenesis and maintenance | IFT80,C10orf2,GFM2,MRPL37,PROL1,TTC21B,MARK4,GABPB1,MTFMT,TCTN3 |
Protein Function
TTBK2 has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TTBK2 itself. We selected most functions TTBK2 had, and list some proteins which have the same functions with TTBK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SCN8A,NOLC1,DNAH5,DDX11,CAMKK2,HK2,MCM6,PLK2,MELK,FGFR1B |
| protein serine/threonine kinase activity | DCKL1B,STK40,BSK146,NUAK1,CSNK1A1,ZNF143B,ADCK4,TSSK3,ICK,CSNK1G2A |
| protein binding | HSPA5,SIVA1,Car4,ZMYM4,PCMT1,HTR3C,DOK4,UVRAG,PPP2R5B,S100P |
Interacting Protein
TTBK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTBK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TTBK2.
CEP164;KLHL12;20555151;CRK;GABARAPL2
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References
- Bender, C; Ullrich, A; et al. PRKX, TTBK2 and RSK4 expression causes sunitinib resistance in kidney carcinoma- and melanoma-cell lines. INTERNATIONAL JOURNAL OF CANCER 131:E45-E55(2012).
