TSTA3
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Official Full Name
tissue specific transplantation antigen P35B -
Overview
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. -
Synonyms
TSTA3;tissue specific transplantation antigen P35B;GDP-L-fucose synthase;FX;GDP L fucose synthase;P35B;SDR4E1;short chain dehydrogenase/reductase family 4E;member 1;3 5 epimerase/4 reductase;anti TSTA3;EC 1.1.1.271;GDP 4 keto 6 deoxy D mannose 35 epimerase 4 reductase;GDP 4 keto 6 deoxy D mannose epimerase reductase;Protein FX;Red cell NADP(H) binding protein;Tissue specific transplantation antigen 3;OTTHUMP00000228670;OTTHUMP00000228671;OTTHUMP00000228672;3-5 epimerase/4-reductase;red cell NADP(H)-binding protein;GDP-4-keto-6-deoxy-D-mannose epimerase-reductase;GDP-4-keto-6-deoxy-D-manno
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- T7
- Non
- His&T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
TSTA3 involved in several pathways and played different roles in them. We selected most pathways TSTA3 participated on our site, such as Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSTA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | SC4MOL,GUK1B,ALDOA,P4HA1,ADH1B,GUSB,IMPDH1B,PLCD1,TYRP1B,PLCB2 |
| Fructose and mannose metabolism | AKR1B1L,TPI1A,MPI,KHK,PMM2,PFKM,GMPPAB,TIGARA,PFKFB4L,ALDOC |
| Amino sugar and nucleotide sugar metabolism | UGDH,FUK,GKUP,RENBP,NANS,GPR19,GNPDA2,CHIT1,GPIA,GALE |
Protein Function
TSTA3 has several biochemical functions, for example, GDP-4-dehydro-D-rhamnose reductase activity,GDP-L-fucose synthase activity,coenzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSTA3 itself. We selected most functions TSTA3 had, and list some proteins which have the same functions with TSTA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| isomerase activity | ECI2,PGAM1,GPI1,ITPK1A,PGAM1B,HSD17B4,PPIFB,ITPK1,PTGESL,HSD3B6 |
| coenzyme binding | WWOX,HMGCRA,TDH2,QDPRB1,GCLC,GCH1,NDUFA9A,NDUFA9,ACAT1,HMGCRB |
| electron carrier activity | ACAD8,IDH3B,AOX4,GSR,SDHD,HSD17B6,GLRX2,NDUFS1,AKR7A3,ALDH4A1 |
Interacting Protein
TSTA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSTA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSTA3.
ID2;RIOK2
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