TSG101
-
Official Full Name
tumor susceptibility 101 -
Overview
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008] -
Synonyms
TSG101;tumor susceptibility 101;TSG10;VPS23;tumor susceptibility gene 101 protein;tumor susceptibility gene 10;tumor susceptibility protein;tumor susceptibility gene 101;ESCRT-I complex subunit TSG101
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Wheat Germ
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- In Vitro Cell Free System
- GST
- His&Myc&SUMO
- His
- Flag
- Non
- His&Fc&Avi
Involved Pathway
TSG101 involved in several pathways and played different roles in them. We selected most pathways TSG101 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSG101 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | SRC,IGF1RB,ACAP3,CDC42,GBF1,ARPC5B,PARD6GA,CCDC53,CDC42L2,ZFYVE9 |
Protein Function
TSG101 has several biochemical functions, for example, DNA binding,calcium-dependent protein binding,ligand-dependent nuclear receptor transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TSG101 itself. We selected most functions TSG101 had, and list some proteins which have the same functions with TSG101. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligand-dependent nuclear receptor transcription coactivator activity | PUS1,MED14,WDR77,ZCCHC12,CCDC62,PRKCBB,SS18,RBM14,PRKCB,MED1 |
| transcription corepressor activity | WWTR1,CIR1,CTBP2A,UBP1,ELK3,ZHX2,AEBP1,JUB,E2F7,HAND1 |
| virion binding | PPIA,APCS,HIPK2,PVRL1,PTX3,HSP90B1,CD209,CLEC4M |
| calcium-dependent protein binding | ALG2,KOP,MBL1,MMP13,CHP,TNNI3,SNAP25,PDCD6IP,PDCD6,ANXA6 |
| ubiquitin binding | CRY2,NEDD4,OTUB2,SMAD3,RNF168,FAN1,IDE,RNF31,RBCK1,PARK2 |
| DNA binding | HIST1H2BP,DNAJC1,PAX1,HIST1H111R,PAX2,ARID5A,UNCX,MTF1,ZNF781,PUF60B |
| protein homodimerization activity | SH3GLB1,GTF2A2,CRYBA1,CEBPA,CD4,PML,ACTN2,KCNH2,CCDC103,OSTA |
| ubiquitin protein ligase binding | DBT,SMAD5,PTPN22,UCHL1,ASB4,RALB,C10orf46,ERLIN2,TMBIM6,GGN |
| protein binding | CCDC41,PIAS4,GOLGA1,TNIP2,RAD9B,CDC25A,SHROOM2,ARL2BP,CERK,SURF1 |
Interacting Protein
TSG101 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSG101 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSG101.
CEP55;VPS28;LRSAM1
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