TRPS1
-
Official Full Name
trichorhinophalangeal syndrome I -
Overview
This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. -
Synonyms
TRPS1;trichorhinophalangeal syndrome I;zinc finger transcription factor Trps1;LGCR;zinc finger protein GC79;tricho-rhino-phalangeal syndrome type I protein;GC79;MGC134928
Recombinant Proteins
- Human
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRPS1-3437H | Recombinant Human TRPS1, His-tagged | E.coli | Human | His | 22-371aa | |
| TRPS1-3193H | Recombinant Human TRPS1 protein, His-tagged | E.coli | Human | His | 1158-1281 aa | |
| TRPS1-7752Z | Recombinant Zebrafish TRPS1 | Mammalian Cells | Zebrafish | His |
|
|
| TRPS1-301463H | Recombinant Human TRPS1 protein, GST-tagged | E.coli | Human | GST | Ser1158-Glu1281 |
|
| TRPS1-3438H | Recombinant Human TRPS1 protein, His-tagged | E.coli | Human | 9-358 aa |
|
|
| TRPS1-3439H | Recombinant Human TRPS1 protein, His-tagged | E.coli | Human | 1158-1281 aa |
|
|
| TRPS1-3440H | Recombinant Human TRPS1 protein, GST-tagged | E.coli | Human | 1158-1281 aa |
|
|
| TRPS1-839HCL | Recombinant Human TRPS1 lysate, MYC/DDK-tagged | HEK293 | Human |
|
Involved Pathway
TRPS1 involved in several pathways and played different roles in them. We selected most pathways TRPS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TRPS1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPS1 itself. We selected most functions TRPS1 had, and list some proteins which have the same functions with TRPS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | LZTS1,MNX2A,TEF,SCAND1,HOMEZ,ALX3,WNT5A,ZFP629,ARNTL2,KLF1 |
| RNA polymerase II regulatory region sequence-specific DNA binding | RFX6,GATA2A,TBX5,ZNF8,GATA2,SP5,BCL6A,CDX1B,SNAI1,ZFP39 |
| chromatin binding | MEIS1,RING1,ASCL1,MBD1,EZH1,TOX2,ARID3C,ISL1,CDC45,SALL1 |
| RNA polymerase II transcription factor binding | TBX20,XBP1,CREBBP,MIXL1,ATF4,MEF2A,GSC,ZFPM1,WWP2,SMAD4 |
| protein binding | ATF6,FKBPL,PTEN,ITGA3,OPRD1,PRKCE,CRNKL1,STUB1,TCHP,TTC9C |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | BARX2,FOXC1,GATA6,GATA1A,GATA3,BARX1,CREB3L4,OSR2,FEZF2,MSX1 |
| zinc ion binding | DTX2,JUB,LDB3,LONRF3,SIAH2,RAG1,MAN2C1,BSPRY,MEP1A,BTR02 |
Interacting Protein
TRPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPS1.
ORF;RNF4;Dynll1;maP3;clpB;CDK2AP1;SEC16A;Tuba3a;MAPK3;DYNLL1;CDK18;HDAC1;MCM6;Mta1;Kctd5;CEP170P1
Resources
Research Area
Apoptosis Transcription Factors and RegulatorsTranscription Factors in the Akt Pathway
Cancer Stem Cell Transcription Factors
Mesenchymal to Epithelial Transition
Related Services
Related Products
References
- Hufeland, M; Rahner, N; et al. Trichorhinophalangeal Syndrome Type I: A Novel Mutation and Perthes-like Changes of the Hip in a Family With 4 Cases Over 3 Generations. JOURNAL OF PEDIATRIC ORTHOPAEDICS 35:E1-E5(2015).
- Pereda, A; Azriel, S; et al. Pseudohypoparathyroidism vs. tricho-rhinophalangeal syndrome: patient reclassification. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 27:1089-1094(2014).
