TRPM8

  • Official Full Name

    transient receptor potential cation channel, subfamily M, member 8

  • Overview

    Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

  • Synonyms

    TRPM8;transient receptor potential cation channel, subfamily M, member 8;TRPP8;LTRPC6;transient receptor potential cation channel subfamily M member 8;trp-p8;LTrpC-6;transient receptor melastatin 8;transient receptor potential p8;short form of the TRPM8 cationic channel;long transient receptor potential channel 6;transient receptor potential subfamily M member 8

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • His&Flag
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRPM8-3436H Recombinant Human TRPM8, GST-tagged E.coli Human GST 66-234aa
TRPM8-3702H Recombinant Human TRPM8 protein, His-tagged E.coli Human His 3-192 aa
TRPM8-1733C Recombinant Chicken TRPM8 Mammalian Cells Chicken His
TRPM8-6302R Recombinant Rat TRPM8 Protein Mammalian Cells Rat His
TRPM8-737HCL Recombinant Human TRPM8 293 Cell Lysate HEK293 Human Non
TRPM8-06H Recombinant Human TRPM8 Protein (Met1-Pro300), N-His-tagged E.coli Human His Met1-Pro300
TRPM8-1170HFL Recombinant Human TRPM8 protein, His&Flag-tagged HEK293 Human His&Flag 1-1104 aa
TRPM8-1171H Recombinant Human TRPM8 protein, His-tagged HEK293 Human His 690-1104aa
TRPM8-35H Recombinant Human TRPM8 protein, His-tagged E.coli Human His 31-162 aa
TRPM8-36H Recombinant Human TRPM8 protein, His-tagged E.coli Human His Glu311-Glu460
TRPM8-5959R Recombinant Rat TRPM8 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
TRPM8-5959R-B Recombinant Rat TRPM8 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    TRPM8 involved in several pathways and played different roles in them. We selected most pathways TRPM8 participated on our site, such as Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inflammatory mediator regulation of TRP channels CYP4A14,CAMK2A,CALM3,TRPV2,CYP4A12A,CYP2C38,PIK3R5,HRH1,CALML3,PPP1CC

    Protein Function

    TRPM8 has several biochemical functions, for example, calcium channel activity,protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPM8 itself. We selected most functions TRPM8 had, and list some proteins which have the same functions with TRPM8. You can find most of the proteins on our site.

    Function Related Protein
    calcium channel activity SLC24A5,TRPC7B,PKD1,TRPV5,TRPC2,MCU,CACFD1,PSEN1,CACNA1DA,SLC24A2
    protein homodimerization activity AGR2,MAP3K11,ASMT,UGT1A7,MIXL1,HNF1B,CADM1B,MCL1,TYW5,EXT1
    protein binding STK11,PEX12,PPP2R3A,TMED5,IL10RB,TNFSF14,ING1,IKBIP,YTHDC1,IKZF2

    Interacting Protein

    TRPM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPM8.

    Resources

    Research Area

    Ion Channels and Regulators

    References

    • Yu, S; Xu, ZY; et al. Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O-2-independent and RACK1-mediated mechanism of HIF-1 alpha stabilization. JOURNAL OF PATHOLOGY 234:514-525(2014).
    • Dussor, G; Yan, J; et al. Targeting TRP Channels For Novel Migraine Therapeutics. ACS CHEMICAL NEUROSCIENCE 5:1085-1096(2014).

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