TRPM2
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Official Full Name
transient receptor potential cation channel, subfamily M, member 2 -
Overview
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. -
Synonyms
TRPM2;transient receptor potential cation channel, subfamily M, member 2;TRPC7;transient receptor potential cation channel subfamily M member 2;EREG1;KNP3;LTRPC2;NUDT9H;NUDT9L1;LTrpC-2;transient receptor potential channel 7;long transient recep
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRPM2-8406Z | Recombinant Zebrafish TRPM2 | Mammalian Cells | Zebrafish | His |
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| TRPM2-1164HFL | Recombinant Human TRPM2 protein, His&Flag-tagged | HEK293 | Human | His&Flag | 1-1503 aa |
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| TRPM2-8450H | Native Human TRPM2 | Human | Human | Non |
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| TRPM2-8463H | Native Human TRPM2 | Human | Human | Non |
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Involved Pathway
TRPM2 involved in several pathways and played different roles in them. We selected most pathways TRPM2 participated on our site, such as Oxytocin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxytocin signaling pathway | NPR1,MYL6,CAMKK1,ROCK2,NFATC3,PIK3R5,PRKAB1,PPP1R12A,PLA2G4A,CAMK4 |
Protein Function
TRPM2 has several biochemical functions, for example, ADP-ribose diphosphatase activity,calcium channel activity,manganese ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPM2 itself. We selected most functions TRPM2 had, and list some proteins which have the same functions with TRPM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| manganese ion transmembrane transporter activity | MMGT2,SLC11A1,SLC11A2,ZP3 |
| sodium channel activity | ASIC1A,SCN8AB,SCNN1G,TRPM5,SCN11A,SCN4AA,SCN12AB,SLC4A11,ASIC1C,PKD2L1 |
| calcium channel activity | CACNA1BA,CACNG8A,AKR1C1,CUL5,ITPR1,PANX1,TRPM1,TRPV5,CACNG2A,CACNG7A |
| ADP-ribose diphosphatase activity | NUDT5,NUDT14,NUDT9,ADPRM |
Interacting Protein
TRPM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPM2.
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References
- Roberge, S; Roussel, J; et al. TNF-alpha-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes. CARDIOVASCULAR RESEARCH 103:90-99(2014).
- Chiu, CG; Nakamura, Y; et al. Genome-Wide Characterization of Circulating Tumor Cells Identifies Novel Prognostic Genomic Alterations in Systemic Melanoma Metastasis. CLINICAL CHEMISTRY 60:873-885(2014).
