TRIM37

  • Official Full Name

    tripartite motif containing 37

  • Overview

    This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.

  • Synonyms

    TRIM37;tripartite motif containing 37;MUL, tripartite motif containing 37;E3 ubiquitin-protein ligase TRIM37;KIAA0898;POB1;RING B box coiled coil protein;TEF3;mulibrey nanism protein;RING-B-box-coiled-coil protein;tripartite motif-containing 37

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • Insect Cells
  • Mammalian Cells
  • Sf9 Cells
  • Wheat Germ
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRIM37-640H Active Recombinant Human TRIM37 Protein, GST-tagged Insect Cells Human GST
TRIM37-1372C Recombinant Chicken TRIM37 Mammalian Cells Chicken His
TRIM37-199H Recombinant Human TRIM37, GST-tagged Sf9 Cells Human GST
TRIM37-31610TH Recombinant Human TRIM37 Wheat Germ Human Non 100 amino acids
TRIM37-4966R Recombinant Rhesus monkey TRIM37 Protein, His-tagged Mammalian Cells Rhesus macaque His
TRIM37-780HCL Recombinant Human TRIM37 293 Cell Lysate HEK293 Human Non
TRIM37-4780R Recombinant Rhesus Macaque TRIM37 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
TRIM37-4780R-B Recombinant Rhesus Macaque TRIM37 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    TRIM37 involved in several pathways and played different roles in them. We selected most pathways TRIM37 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM37 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis TCEB1,BIRC2,UBE2K,UBE2G1B,CUL4A,CUL1B,CUL1,UBE2Q1,CDH1-A,BIRC3

    Protein Function

    TRIM37 has several biochemical functions, for example, chromatin binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM37 itself. We selected most functions TRIM37 had, and list some proteins which have the same functions with TRIM37. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding MDM4,QPCTLA,ADAM20,ING5,MPI,ZDHHC16A,LPP,ZMIZ2,RNF139,MGRN1B
    chromatin binding APITD1,DMRT1,KLHDC3,TRPS1,SOX9A,WACA,HMGXB4A,ZKSCAN3,UBE2T,FOSL2
    tumor necrosis factor receptor binding BRE,TNFSF14,TNFSF10L4,Fasl,TNFSF4,TNF,TNFSF12,LTB,TRAF6,ERAP1
    ubiquitin-protein transferase activity TRAF4B,MYCBP2,FBXL7,UBE2D4,UBE2E3,RNF31,UHRF2,RNF6,TRIM32,LNX2B
    ubiquitin protein ligase binding HSPA5,CUL4A,CUL1,UBE2V2,UBXN1,PRKAR1A,EIF4E2,DIO2,CCT2,FANCL
    ligase activity SH3RF2,HECTD3,RNF43,CBX4,RAG1,RNF220,TRIM5,PCXB,UBR1,BIRC3
    ubiquitin protein ligase activity FBXL22,RNF139,MED10,MED1,FLJ11011L,ANAPC11,SMURF1,XIAP,TRIM6,WWP1
    protein homodimerization activity YARS2,ODZ4,HER5,WWTR1,TNNC1,SNX9,PRLR,PON1,SEPHS1,ADD2
    protein binding ERO1LB,PEX11B,MAP2K1,TTC25,RMND5A,MAB21L2,SF1,TFR2,GRHL2,KCP

    Interacting Protein

    TRIM37 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM37 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM37.

    BYSL;ZNF417;MCRS1;PRC1;a8k932_human

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