TRIM37
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Official Full Name
tripartite motif containing 37 -
Overview
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified. -
Synonyms
TRIM37;tripartite motif containing 37;MUL, tripartite motif containing 37;E3 ubiquitin-protein ligase TRIM37;KIAA0898;POB1;RING B box coiled coil protein;TEF3;mulibrey nanism protein;RING-B-box-coiled-coil protein;tripartite motif-containing 37
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Insect Cells
- Mammalian Cells
- Sf9 Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRIM37-640H |
Active Recombinant Human TRIM37 Protein, GST-tagged
|
Insect Cells | Human | GST |
|
|
| TRIM37-1372C | Recombinant Chicken TRIM37 | Mammalian Cells | Chicken | His |
|
|
| TRIM37-199H | Recombinant Human TRIM37, GST-tagged | Sf9 Cells | Human | GST |
|
|
| TRIM37-31610TH | Recombinant Human TRIM37 | Wheat Germ | Human | Non | 100 amino acids |
|
| TRIM37-4966R | Recombinant Rhesus monkey TRIM37 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
|
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| TRIM37-780HCL | Recombinant Human TRIM37 293 Cell Lysate | HEK293 | Human | Non |
|
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| TRIM37-4780R | Recombinant Rhesus Macaque TRIM37 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
|
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| TRIM37-4780R-B | Recombinant Rhesus Macaque TRIM37 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
|
Involved Pathway
TRIM37 involved in several pathways and played different roles in them. We selected most pathways TRIM37 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM37 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | UBE2IB,MGRN1,VHL,COP1,ANAPC2,SOCS3B,CDH1-A,CDC26,CUL4B,RBX1 |
Protein Function
TRIM37 has several biochemical functions, for example, chromatin binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM37 itself. We selected most functions TRIM37 had, and list some proteins which have the same functions with TRIM37. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | MIB1,RNF168,PARK2,TRIM56,PEX12,TRIM33,FBXO4,UBE2W,UBE2L3,ZNRF1 |
| tumor necrosis factor receptor binding | TNF,TRAF1,TNFSF15,LTB,FASLG,TNFSF10L4,TNFSF11,CD70,TNFSF14,TNFSF13B |
| zinc ion binding | MARCH7,ZSWIM4,PNMA3,KMT2A,SEC23A,FHL3B,PCGF2,BRF1A,RBCK1,SYVN1 |
| protein binding | NPPA,CCS,METAP2,MGST1,ALDH7A1,STXBP3A,CRB1,EHMT2,EGFR,CC10 |
| chromatin binding | EZH2,NCOA1,HMGB3A,JDP2,KIAA0101,HDAC4,FOXN4,CRX,NOC3L,SP140 |
| ubiquitin protein ligase binding | PACRG,KDM4A,AICDA,TPI1,RPA3,HSPA9,BAG5,CLU,NPLOC4,MYOD1 |
| protein homodimerization activity | Fzd4,SYNDIG1,ALDH1A3,LRRK2,SERPINF2,IDE,NOS1,ACCS,CSF1R,SPPL2B |
| ligase activity | RNF111,KCMF1,MARCH11,RNF19A,TRIML1,PIAS3,UBR2,UBE2G1B,UBE3A,MUL1 |
| ubiquitin protein ligase activity | RNF115,PPIL2,ANKIB1A,BTRC,CBLC,BFAR,DZIP3,SMURF2,MDM2,RNF220 |
Interacting Protein
TRIM37 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM37 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM37.
BYSL;ZNF417;MCRS1;PRC1;a8k932_human
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