TRIM32
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Official Full Name
tripartite motif containing 32 -
Overview
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. -
Synonyms
TRIM32;tripartite motif containing 32;LGMD2H, limb girdle muscular dystrophy 2H (autosomal recessive) , tripartite motif containing 32;E3 ubiquitin-protein ligase TRIM32;BBS11;HT2A;TATIP;72 kda Tat interacting Protein;LGMD2H;Limb girdle muscular dystrophy 2H (autosomal recessive);Limb girdle muscular dystrophy 2H;Muscular dystrophy Hutterite type;TAT interactive protein 72KD;Tripartite Motif Containing Protein 32;Zinc Finger Protein HT2A;OTTHUMP00000022763;zinc-finger protein HT2A;72 kDa Tat-interacting protein;TAT-interactive protein, 72-KD;tripartite motif-containing 32;tripartite motif-containing protein 32
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- Sf9 Cells
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi&Fc&His
- DDK&Myc
- Flag
Involved Pathway
TRIM32 involved in several pathways and played different roles in them. We selected most pathways TRIM32 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM32 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | UBE2G2,UBE2D1A,RBX1,WWP2,CDC27,SIAH1,TRIP12,BTRC,TCEB1,SIAH2L |
Protein Function
TRIM32 has several biochemical functions, for example, RNA binding,Tat protein binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM32 itself. We selected most functions TRIM32 had, and list some proteins which have the same functions with TRIM32. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | MARCH2,UBE2R2,UBE3A,STUB1,TRIM21,PDZRN3,RNF125,UBE2N,MUL1A,MGRN1 |
| protein self-association | CBR2,PABPN1,VAMP2,SYP,DVL2,PTH1R,DYRK1A,NKX3-1,S100A7A,CTSB |
| myosin binding | CALD1B,CALM,ARFGEF2,ACTA1,ACTC1,SMYD1B,DMD,USH2A,GIPC1,VAMP2 |
| translation initiation factor binding | ZFP259,POLR2D,ZNF259,EIF2B4,EIF2B3,EIF3F,LIN28A,RPS24,POLR2GL,DDX3X |
| zinc ion binding | MUL1,ADAM33,FAM90A1,FANCL,TRAF2,DUSP12,NR6A1B,LHX2B,DPF3,ZDHHC20A |
| ubiquitin protein ligase activity | TRIM6,COP1,UBE3C,RNF222,HECTD3,RBBP6,UBE2KB,UBE2R2,TRIM72,RNF13 |
| RNA binding | NHP2L1B,HENMT1,PES,HNRPKL,HNRPK,RPS9,ELAVL1,CTU1,CNOT6,CELF5 |
| ligase activity | ADSSL,UBR3,RNF187,MGRN1,ZSWIM2,SIAH2L,ZNRF3,MDM2,UBR7,RNF14 |
| transcription coactivator activity | MAML1,TRIP4,NR2F1,HSF2,NR1I2,ECD,TRIM24,PMF1,SMARCA2,USP22 |
Interacting Protein
TRIM32 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM32 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM32.
PDE9A;SCGB1A1;UBE2U;UBQLN1;b3kpu6_human
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