TRIM3
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Official Full Name
tripartite motif containing 3 -
Overview
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the RING-B-box-coiled-coil (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. -
Synonyms
TRIM3;tripartite motif containing 3;RNF22, tripartite motif containing 3;tripartite motif-containing protein 3;BERP;brain expressed ring finger;HAC1;ring finger protein 22;RNF97;tripartite motif protein TRIM3;Brain-expressed RING finger protein;FLJ16135;RING finger protein 97;RNF22;TRIM3_HUMAN;tripartite motif-containing 3
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TRIM3 involved in several pathways and played different roles in them. We selected most pathways TRIM3 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | IL17RD,FRS2,DUSP1,TRIM5,MAP3K8,IL1RN,CRKL,HAVCR2,TRIM22,IFI35 |
| Interferon gamma signaling | GBP5,TRIM45,TRIM8,OASL,TRIM48,TRIM68,TRIM10,TRIM6,TRIM5,IRF4 |
| Interferon Signaling | SAMHD1,TRIM68,IFIT14,IFIT12,TRIM62,IFIT3,GBP1,EIF4G2A,ARIH1,IFIT8 |
| Immune System | KIR3DS1,RCA2.1,LILRB2,TREML1,CD200R3,CASPBL,SIGIRR,TAX1BP1,PVRL2L,CTS7 |
Protein Function
TRIM3 has several biochemical functions, for example, protein C-terminus binding,protein binding,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM3 itself. We selected most functions TRIM3 had, and list some proteins which have the same functions with TRIM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | UBR1,RAD18,RNF222,ZNRF2,RNF122,PDZRN3B,SMURF2,RNF2,UBE2KA,TRIM2 |
| protein C-terminus binding | DLG4,PHB2,ERCC4,SIAH1A,ITGB3BP,VPS4A,VPS36,NCL,NEFL,TNNI3K |
| protein binding | AKTIP,FLOT1,RPS6KB1,HARS2,PLEKHG6,SMG9,ASXL1,DDX39B,DCPS,NANOS2 |
| zinc ion binding | RNF220A,LMO7B,MBD1B,SIAH2L,RBM5,PPARG,ZADH2,CPO,NANOS2,SQSTM1 |
Interacting Protein
TRIM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM3.
UBE2G2;UBE2U;cutF
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References
- Sun, Y; Ho, GH; et al. Down-regulation of Tripartite-motif containing 22 expression in breast cancer is associated with a lack of p53-mediated induction. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 441:600-606(2013).
- Alloush, J; Roof, SR; et al. Expression levels-of sarcolemmal membrane repair proteins following prolonged exercise training in mice. INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 50:428-435(2013).
