TRIM22

  • Official Full Name

    tripartite motif containing 22

  • Overview

    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferons antiviral effects. Alternative splicing results in multiple transcript variants.

  • Synonyms

    TRIM22;tripartite motif containing 22;E3 ubiquitin-protein ligase TRIM22;GPSTAF50;RNF94;STAF50;50 kDa stimulated trans acting factor;RING finger protein 94;Staf 50;Stimulated trans acting factor (50 kDa);Stimulated Trans Acting Factor (homolog of Mouse Rpt 1 gene);Tripartite binding motif 22;Tripartite motif containing protein 22;staf-50;tripartite motif-containing 22;tripartite motif protein TRIM22;50 kDa-stimulated trans-acting factor;tripartite motif-containing protein 22;stimulated trans-acting factor (50 kDa)
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRIM22-4955R Recombinant Rhesus monkey TRIM22 Protein, His-tagged Mammalian Cells Rhesus macaque His
TRIM22-563H Recombinant Human TRIM22 Protein, GST-His-tagged E.coli Human His&GST
TRIM22-790HCL Recombinant Human TRIM22 293 Cell Lysate HEK293 Human Non
TRIM22-4769R Recombinant Rhesus Macaque TRIM22 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
TRIM22-4769R-B Recombinant Rhesus Macaque TRIM22 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    TRIM22 involved in several pathways and played different roles in them. We selected most pathways TRIM22 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System LILRB4,MGC174857,EIF4E3,ISG20,PAG1,MGC174152,LILRB2,LRRFIP1,POLR3C,SUGT1
    Interferon gamma signaling TRIM2,GBP5,GBP6,TRIM62,IRF4,FCGR1B,TRIM31,TRIM68,TRIM45,TRIM26
    Interferon Signaling HERC5,GBP5,EIF4G2,TRIM10,TRIM48,IRF2,IFIT8,OASL,GBP2,TRIM45
    Cytokine Signaling in Immune system EIF4E3,FRS2B,RASGRP4,HAVCR2,SPTBN1,SOCS3A,IFI35,WDR83,KPNA4,USP18

    Protein Function

    TRIM22 has several biochemical functions, for example, ligase activity,protein binding,protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM22 itself. We selected most functions TRIM22 had, and list some proteins which have the same functions with TRIM22. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity ZNRF1,RNF2,UBR2,RNF220,GLULB,TRIM23,SIAH1A,MYLIPB,SMURF1,CDC34A
    transcription corepressor activity PPP1R13L,APEX1,ENO1,SKOR1A,NAB2,ARHGAP35,DMAP1,TBL1XR1,WTIP,BASP1
    protein binding TBX24,HNRNPC,KATNAL1,FAM164A,IRF8,DYNLRB1,EPHA4,C9orf78,NPL,GNAS
    transcription factor activity, sequence-specific DNA binding GATA1,SPI1,TFAP2B,ZNF79,FOXP3,RXRB,TADA2A,HIVEP3,KDM5B,RREB1
    protein kinase binding KIF20A,PTPRC,DNAJC3,FAM83D,LCK,MAP3K12,RNF138,AKAP5,LATS1,BCL2L14
    zinc ion binding FHL1B,C6AST3,RNF139,PDZRN3,KDM7AB,DPF3,MMP28,PHF20L1,ZDHHC15,SLC30A8
    protein binding, bridging PPP2R3A,LOR,TCAP,CNTLN,ANK2,FLRT2,NUFIP1,SYNM,FSCN2B,BCL3

    Interacting Protein

    TRIM22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM22 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM22.

    CASK;q5nes5_fratt;rho;rpoB;glcD3;yezC;USP7;CIC;RERE

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