TRIM13
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Official Full Name
tripartite motif containing 13 -
Overview
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. -
Synonyms
TRIM13;tripartite motif containing 13;ret finger protein 2 , RFP2, tripartite motif containing 13;E3 ubiquitin-protein ligase TRIM13;DLEU5;Leu5;RNF77;ret finger protein 2;RING finger protein 77;CLL-associated RING finger;tripartite motif protei
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mus musculus
- Bovine
- zebrafish
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mouse
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
TRIM13 involved in several pathways and played different roles in them. We selected most pathways TRIM13 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TRIM13 has several biochemical functions, for example, ligase activity,protein binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM13 itself. We selected most functions TRIM13 had, and list some proteins which have the same functions with TRIM13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | PELI3,NEURL1B,RNF115,TRIM39,SIAH2L,MDM2,RNF168,TRIM62,RBX1,TRIM6 |
| signal transducer activity | IL1RAP,PTGER1A,RGS11,V2RH32,OLFCG5,GULP1,PLCD3A,PRMT2,BCAR1,CCR12A |
| protein binding | BLVRA,MUC5B,CTU2,FYN,DHX36,ALOX12,BCL2L10,VCL,HSPA5,GNL3 |
| ubiquitin-protein transferase activity | UBE2D3,FBXO3,UBE2O,FBXO2,PRP19,BIRC5,MUL1B,RNF31,TRIM33,BTR22 |
| zinc ion binding | SUV39H1B,SIRT5,FUS,ZNF212,BARD1,LIMA1,SQSTM1,PTPN1,RNF130,PDLIM5A |
Interacting Protein
TRIM13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM13 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM13.
FLJ13057
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References
- Zoumpoulidou, G; Broceno, C; et al. Role of the Tripartite Motif Protein 27 in Cancer Development. JOURNAL OF THE NATIONAL CANCER INSTITUTE 104:941-952(2012).
- Gatt, ME; Takada, K; et al. TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity. BRITISH JOURNAL OF HAEMATOLOGY 162:210-220(2013).
