TRIB3
-
Official Full Name
tribbles pseudokinase 3 -
Overview
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq, Jul 2008] -
Synonyms
TRIB3;tribbles pseudokinase 3;NIPK;SINK;TRB3;SKIP3;C20orf97;tribbles homolog 3;TRB-3;p65-interacting inhibitor of NF-kappaB;p65-interacting inhibitor of NF-kappa-B;neuronal cell death inducible putative kinase;neuronal cell death-inducible putative kinase
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- Insect Cells
- E.coli
- Mammalian Cells
- Sf9 Cells
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- GST
- His
- Non
- GST&His
- Avi&Fc&His
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRIB3-3073H | Recombinant Human TRIB3 protein(Met1-Gly358), GST-tagged | Insect Cells | Human | GST | Met1-Gly358 | |
| TRIB3-3114H | Recombinant Human TRIB3 protein, His-tagged | E.coli | Human | His | 1-144 aa | |
| TRIB3-12130Z | Recombinant Zebrafish TRIB3 | Mammalian Cells | Zebrafish | His |
|
|
| TRIB3-25H | Recombinant Human TRIB3, GST-tagged | Sf9 Cells | Human | GST |
|
|
| TRIB3-30123TH | Recombinant Human TRIB3 | Wheat Germ | Human | Non | 358 amino acids |
|
| TRIB3-6268R | Recombinant Rat TRIB3 Protein | Mammalian Cells | Rat | His |
|
|
| TRIB3-657HCL | Recombinant Human TRIB3 cell lysate | Insect Cells | Human | Non |
|
|
| TRIB3-0563H | Recombinant Human TRIB3 Protein (R2-G358), His/GST tagged | Insect Cells | Human | GST&His | R2-G358 |
|
| TRIB3-0564H | Recombinant Human TRIB3 Protein (R2-G358), Tag Free | Insect Cells | Human | Non | R2-G358 |
|
| TRIB3-301436H | Recombinant Human TRIB3 protein, GST-tagged | E.coli | Human | GST | Met1-Met144 |
|
| TRIB3-536HF | Recombinant Full Length Human TRIB3 Protein | In Vitro Cell Free System | Human | Full L. 358 amino acids |
|
|
| TRIB3-5925R | Recombinant Rat TRIB3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
|
|
| TRIB3-5925R-B | Recombinant Rat TRIB3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| Trib3-656M | Recombinant Mouse Trib3 protein, His&Myc-tagged | E.coli | Mouse | His&Myc | 1-354aa |
|
Involved Pathway
TRIB3 involved in several pathways and played different roles in them. We selected most pathways TRIB3 participated on our site, such as Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | NFKBIAB,PTPN1,PPP1CBL,PTENA,INSRB,PRKAB1A,MAPK9,PRKCBA,PPP2R4,PPP1CB |
Protein Function
TRIB3 has several biochemical functions, for example, ATP binding,NOT kinase activity,mitogen-activated protein kinase kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIB3 itself. We selected most functions TRIB3 had, and list some proteins which have the same functions with TRIB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | DLG3,CUL5A,PIAS1,EGFR,YWHAZ,HSPA8,RNF31,AURKA,Fzd4,RFFL |
| protein binding | TBCEL,ZNF559,STUB1,TMEM30A,HSPB11,NTRK3,CEP57L1,ILF2,KRTAP3-2,INPP5K |
| protein kinase inhibitor activity | CISHB,TESC,CAMK2N1A,SOCS1,MBIP,TRIB2,SOCS6B,NCK1,SH3BP5B,TSACC |
| ATP binding | MYH15,PKM2,ABCD4,ABCC12,PIP5K1C,CCT2,SLK,RIMKLA,OXSR1A,MKKS |
| transcription corepressor activity | SKI,BASP1,PEX14,ELK3,TFAP2B,CRYM,CIR1,DRAP1,SP100,SSX1 |
| protein kinase binding | APC,MVP,SYK,SPRED1,DLG1,NEFH,MAML1,CCND3,FAM83E,MSN |
| mitogen-activated protein kinase kinase binding | ACE,IGBP1,KSR1,BRAF,TRIB2,RAF1,ARRB1,TRIB1,MAPK8IP3,DLG1 |
| NOT kinase activity | SCYL3 |
| ubiquitin-protein transferase regulator activity | TRIB1,TRIB2 |
Interacting Protein
TRIB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIB3.
ATF4;ATF4;RPGRIP1;PRMT5;MAP2K7;MAP2K1;GDF9;EEF1G;SETDB1;RBM48
Resources
Related Services
Related Products
References
- Locatelli, SL; Giacomini, A; et al. Perifosine and sorafenib combination induces mitochondrial cell death and antitumor effects in NOD/SCID mice with Hodgkin lymphoma cell line xenografts. LEUKEMIA 27:1677-1687(2013).
- Wennemers, M; Stegeman, H; et al. Hypoxia regulation of phosphokinases and the prognostic value of pAKT in breast cancer. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS 28:151-160(2013).
