TRADD

  • Official Full Name

    TNFRSF1A-associated via death domain

  • Overview

    Apoptosis mediated by death factors like FasL and TNF-alpha involves the formation of a death-inducing signaling complex (DISC) to their respective receptors (1). Upon ligand activation to their receptors, Fas and TNF-R1 associate with death domain (DD) c

  • Synonyms

    TRADD;TNFRSF1A-associated via death domain;tumor necrosis factor receptor type 1-associated DEATH domain protein;Hs.89862;TNFR1-associated death domain protein;tumor necrosis factor receptor-1-associated protein;tumor necrosis factor receptor type 1 associated death domain protein;MGC11078

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • His&T7
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRADD-3383H Recombinant Human TRADD protein, His-tagged E.coli Human His 1-312 aa
TRADD-3384H Recombinant Human TRADD protein, His-tagged E.coli Human His Met61~Leu297
TRADD-29977TH Recombinant Human TRADD, His-tagged E.coli Human His Full L. 1-150 a.a.
TRADD-9147Z Recombinant Zebrafish TRADD Mammalian Cells Zebrafish His
TRADD-826HCL Recombinant Human TRADD 293 Cell Lysate HEK293 Human Non
Tradd-1415M Recombinant Mouse Tradd protein, His & T7-tagged E.coli Mouse His&T7 Ser21~Leu259
Tradd-1416R Recombinant Rat Tradd protein, His & T7-tagged E.coli Rat His&T7 Asp24~Glu261
TRADD-4420H Recombinant Human TRADD protein, GST-tagged E.coli Human GST 1-312aa
TRADD-6657H Recombinant Human TRADD Protein (Met61-Leu297), N-His tagged E.coli Human His Met61-Leu297

    Involved Pathway

    TRADD involved in several pathways and played different roles in them. We selected most pathways TRADD participated on our site, such as NF-kappa B signaling pathway,Sphingolipid signaling pathway,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRADD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epstein-Barr virus infection HSPA1A,SNW1,TP53,ENTPD1,PIK3R5,LYN,EIF2AK1,POLR3C,NFKB1,HSPA8
    Hepatitis C MAPK9,TRP53,TRAF6,CLDN16,LDLR,PIK3R2,OAS3,CLDN9,CLDN22,NR1H3
    Viral carcinogenesis PMAIP1,HPN,HIST1H4G,VDAC3,VAC14,SYK,SNW1,PRKACB,TRAF1,PIK3CD
    Tuberculosis FCGR2A,NFKB1,Il23a; Il12b,IFNA13,CORO1A,RAB7A,CAMK2A,CYCS,Cd209g,RELA
    Adipocytokine signaling pathway TNFRSF1B,PRKAA1,ACSL5,PRKAB1A,ACSL3B,PTPN11B,JAK2,MAPK9,PRKAB2,ADIPOR1B
    Apoptosis PANK1A,PIK3CD,STK24,PPP3R1,GZMF,AKT2,JUN,ENDOG,IL1RAP,BOKA
    NF-kappa B signaling pathway Ccl21a,BCL2,BCL2L1,CXCL2,TNFSF14,CCL4L2,CCL21,TLR4,BCL2A1,DDX58
    TNF signaling pathway MAP3K7,TRAF3,MAP3K14,AKT2,MAPK13,IL6,CXCL3,PIK3R1,CXCL5,MAPK10
    RIG-I-like receptor signaling pathway TRAF6,AZI2,ATG12,TRAF3,MAP3K7,IKBKG,MAPK14A,IL12B,IFNA4,IFNA16

    Protein Function

    TRADD has several biochemical functions, for example, binding, bridging,death domain binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRADD itself. We selected most functions TRADD had, and list some proteins which have the same functions with TRADD. You can find most of the proteins on our site.

    Function Related Protein
    signal transducer activity PLEKHG5,PLCG2,PLK2,VALOPA,GNA11A,HTR1D,OLFR8,VMN1R47,TAAR6,PLCD1
    kinase binding PER3,SNAI1,PRKAA1,HSP90AB1,CHP1,DLG4,CHP,UBQLN1,MIDN,TNFAIP3
    binding, bridging PDCD6,GAS6
    death domain binding RIPK1,DAPL1,DAP,DAP1B,CRADD
    protein binding CRYBB3,ACTN4,SALL4,CCDC41,ORAI1,VEZT,MAPK13,KXD1,IMPA2,KIAA0368
    identical protein binding DAAM1,TPRGL,CLDN15,CALHM1,PNMA5,SERPINA1A,GPR50,UBE2G2,DAPK1,USP2
    protein complex binding SH2B3,LRRC16A,CDH2,TAPBPL,ADM2,ATG101,PLK2,NDUFA4,RARB,ABI2
    tumor necrosis factor receptor binding TNFSF14,TNFSF8,TNFSF13B,TNFSF13,FADD,CD40LG,TRAF1,TNF,TNFSF10L,BRE

    Interacting Protein

    TRADD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRADD here. Most of them are supplied by our site. Hope this information will be useful for your research of TRADD.

    TNFRSF1A;TRAF2

    Resources

    Research Area

    Apoptosis Adaptor Proteins
    Adaptor Proteins
    Adaptor Proteins in the Akt Pathway
    RIG-I-like Receptors

    References

    • Hu, R; Du, QM; et al. Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment. FEBS LETTERS 588:401-407(2014).
    • Hirsch, B; von der Wall, E; et al. RIP1 expression is necessary for CD30-mediated cell death induction in anaplastic large-cell lymphoma cells. LABORATORY INVESTIGATION 93:677-689(2013).

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