TPSG1
-
Official Full Name
tryptase gamma 1 -
Overview
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. -
Synonyms
TPSG1;tryptase gamma 1;tryptase gamma;PRSS31;TMT;tryptase gamma I;tryptase gamma II;gamma I;gamma II;lung tryptase;skin tryptase;mast cell tryptase;pituitary tryptase;serine protease 31;mast cell protease II;transmembrane tryptase;trpA
Recombinant Proteins
- Human
- Rhesus macaque
- Mus musculus
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- Avi&Fc&His
- DDK&Myc
Involved Pathway
TPSG1 involved in several pathways and played different roles in them. We selected most pathways TPSG1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TPSG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TPSG1 has several biochemical functions, for example, serine-type endopeptidase activity,serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TPSG1 itself. We selected most functions TPSG1 had, and list some proteins which have the same functions with TPSG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | TMPRSS11B,PRSS59.2,HTRA2,TMPRSS4,PIK3IP1,GZMK,HP,PRSS42,C1R,PCSK9 |
| serine-type peptidase activity | KLK7,C1R,HTRA2,GZMM,KLK15,PRSS3,DPP4,KLK1B11,PARLA,TRY |
Interacting Protein
TPSG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPSG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPSG1.
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References
- Kritas, SK; Saggini, A; et al. MAST CELL INVOLVEMENT IN RHEUMATOID ARTHRITIS. JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS 27:655-660(2013).
- Lappalainen, J; Lindstedt, KA; et al. OxLDL-IgG immune complexes induce expression and secretion of proatherogenic cytokines by cultured human mast cells. ATHEROSCLEROSIS 214:357-363(2011).
