TPSAB1
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Official Full Name
tryptase alpha/beta 1 -
Overview
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3 UTR and contain tandem repeat sequences at the 5 flank and 3 UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. -
Synonyms
TPSAB1;tryptase alpha/beta 1;TPS1, TPS2, TPSB1, tryptase beta 1;tryptase alpha/beta-1;tryptase alpha II;tryptase beta I;tryptase I;tryptase II;tryptase III;tryptase-1;tryptase-I;tryptase-III;tryptase beta 1;tryptase beta-1;tryptase alpha-1
Recombinant Proteins
- Cynomolgus
- Mouse
- Rat
- Human
- N-His
- E.coli
- Lung
- Mouse myeloma cell
- Yeast
- Insect Cells
- Mammalian Cells
- His
- Non
- His&Myc&SUMO
Involved Pathway
TPSAB1 involved in several pathways and played different roles in them. We selected most pathways TPSAB1 participated on our site, such as Activation of Matrix Metalloproteinases,Degradation of the extracellular matrix,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPSAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Degradation of the extracellular matrix | MMP12,ADAM9,NID1,CTSS,CTSK,MMP8,COL25A1,CMA1,CTSG,MGC174857 |
| Extracellular matrix organization | ADAMTS18,CEACAM8,JAM2B,MGC174857,MFAP2,FN1B,LRP4,CD151,CTSD,DAG1 |
| Activation of Matrix Metalloproteinases | LOC100686744,MMP13,FURINB,CTSK,TIMP2B,MMP10,TIMP2A,MGC174155,TIMP2,MMP11 |
Protein Function
TPSAB1 has several biochemical functions, for example, protein binding,serine-type endopeptidase activity,serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TPSAB1 itself. We selected most functions TPSAB1 had, and list some proteins which have the same functions with TPSAB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | PRSS7,PCSK5,ST14A,TMPRSS4B,PRSS57,ST14,TMPRSS5,TMPRSS13B,PCSK5B,Prss32 |
| serine-type peptidase activity | TRY,ELA3L,TPSG1,C1RA,ST14,GZMM,TMPRSS12,CMA1,GZMK,KLK15 |
| protein binding | ATL1,TP53INP1,PPIG,GTF2H3,MDH1,CDKN3,SAP30L,EPRS,SPSB3,ID1 |
Interacting Protein
TPSAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPSAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPSAB1.
NCK1;PIK3R1
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