TPK1
-
Official Full Name
thiamin pyrophosphokinase 1 -
Overview
This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. -
Synonyms
TPK1;thiamin pyrophosphokinase 1;HTPK1;placental protein 20;PP20;thiamine diphosphokinase;thiamine kinase;thiamine pyrophosphokinase 1;OTTHUMP00000202345;OTTHUMP00000202346;OTTHUMP00000241315
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Arabidopsis thaliana
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- Mammalian cells
- HEK293T
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
TPK1 involved in several pathways and played different roles in them. We selected most pathways TPK1 participated on our site, such as Thiamine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thiamine metabolism | NTPCR,THTPA,NFS1 |
| Metabolic pathways | MCCC1,ANPEP,GLDC,DHRS4,ST6GALNAC6,NDUFA1,DPM1,EXT1B,DCT,CCBL1 |
Protein Function
TPK1 has several biochemical functions, for example, ATP binding,kinase activity,thiamine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPK1 itself. We selected most functions TPK1 had, and list some proteins which have the same functions with TPK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase activity | ACVR2AA,CSNK1G2A,STK25B,CDK5R1A,CCL3,MAPKAPK2A,SMOK2B,GRK7A,MAP2K4A,TNK2B |
| ATP binding | UPF1,ORC5,ABCC12,LATS1,PIK3C2A,MARS,UBE2J1,HIPK4,PSMC6,CAMKK1B |
Interacting Protein
TPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPK1.
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References
- Brena, S; Cabezas-Olcoz, J; et al. Fungicidal Monoclonal Antibody C7 Interferes with Iron Acquisition in Candida albicans. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 55:3156-3163(2011).
- Kronberg, F; Giacometti, R; et al. Characterization of the regulatory subunit of Yarrowia lipolytica cAMP-dependent protein kinase. Evidences of a monomeric protein. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 509:66-75(2011).
