TPI1
-
Official Full Name
triosephosphate isomerase 1 -
Overview
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. -
Synonyms
TPI1;triosephosphate isomerase 1;triosephosphate isomerase;MGC88108;TIM;TPI 1;TPI;Triose phosphate isomerase 1;Triose phosphate isomerase;OTTHUMP00000165244;triose-phosphate isomerase
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Bovine
- E.coli
- Mammalian Cells
- HEK293
- Nicotiana Benthamiana
- His
- Non
- His&Strep
- Flag
- His&Fc&Avi
- GST
- Myc&DDK
- His&Myc
Involved Pathway
TPI1 involved in several pathways and played different roles in them. We selected most pathways TPI1 participated on our site, such as Glycolysis / Gluconeogenesis,Fructose and mannose metabolism,Inositol phosphate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | INPPL1,PIK3CB,ISYNA1,MTM1,INPP5D,PI4K2A,NUDT10,NUDT3A,PLCZ1,PLCG1 |
| Biosynthesis of amino acids | ENO1A,GPT2,ASL,ALDOCB,GLULB,ENO1B,MAT2A,PSPH,PKMA,CBSA |
| Glycolysis / Gluconeogenesis | GALM,ALDOB,ALDH3B2,GAPDHS,PFKP,ALDH9A1B,PKM,PGAM2,GAPDH,FBP2 |
| Carbon metabolism | ACO1,PKLR,PKM,ACADM,SHMT1,HAO2,RGN,ACSS2L,DLST,TPI1B |
| Fructose and mannose metabolism | GMDS,PFKFB4,ALDOC,ALDOCA,ALDOB,HK2,PFKP,AKR1B1,PFKM,AKR1B7 |
| Metabolic pathways | HMGCS2,PFKMB,HSD3B7,B3GALT5,SC5D,PTDSS2,LYCAT,POLD1,GALT,ALDH1B1 |
Protein Function
TPI1 has several biochemical functions, for example, protein binding,triose-phosphate isomerase activity,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPI1 itself. We selected most functions TPI1 had, and list some proteins which have the same functions with TPI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| triose-phosphate isomerase activity | TPI1A,TPI1B |
| ubiquitin protein ligase binding | ANKRD32,TRAF4,SMAD3,FBXW7,PER3,CUL5A,JKAMP,OTUB1,ARRB1,MDM2 |
| protein binding | EPHA10,FLCN,XRCC4,PPP3CA,CD36,E2F7,IL24,CASK,NAV2,STAU2 |
Interacting Protein
TPI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPI1.
PCNA;TERF1;SP1;YWHAZ;EGFR;CCL11;SETDB1;MAPK6;DDX24;POT1;LIPT1;ere_dna;GABARAP;NS;ATF2;polg_hcvh
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