TP53BP1
-
Official Full Name
tumor protein p53 binding protein 1 -
Overview
May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage. -
Synonyms
TP53BP1;tumor protein p53 binding protein 1;p202;53BP1;tumor suppressor p53-binding protein 1;p53BP1;p53-binding protein 1;tumor protein 53-binding protein, 1;tumor protein p53-binding protein, 1
Recombinant Proteins
- Human
- Zebrafish
- CHO
- E.coli
- Mammalian Cell
- Mammalian cells
- HEK293
- Protein Modification
- HEK293T
- His
- GST
- Flag
- His&Fc&Avi
- Myc&DDK
- N-His and N-GFP
Involved Pathway
TP53BP1 involved in several pathways and played different roles in them. We selected most pathways TP53BP1 participated on our site, such as Cell Cycle,Cell Cycle Checkpoints,DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP53BP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G2/M Checkpoints | BRE,RAD17,BARD1,RNF168,HUS1,RAD9B,UIMC1,THRSP,RAD9,RAD1 |
| DNA Double Strand Break Response | EYA4,BAZ1B,FAM175A,UIMC1,THRSP,UBE2V2,BRE,RAD50,EYA3,CHEK2 |
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | UIMC1,RAD1,TIPIN,EME2,THRSP,GEN1,PPP4R2,RBBP8,KIAA0146,BRE |
| Cell Cycle Checkpoints | CHEK1,RAD9A,HTATIP,BRCC3,BABAM1,RAD50,CLSPN,MCM10,HIST4H4,MCM8 |
| G2/M DNA damage checkpoint | THRSP,FAM175A,BRCC3,BRE,BARD1,BABAM1,UIMC1,RNF168 |
| DNA Repair | DNA2,RNF4,ZFP830,DCLRE1A,KIAA0146,MCRS1,SPRTN,PPP4R2,BAZ1B,COPS2 |
| Cell cycle | ESPL1,TUBGCP4,FOXM1,MYCA,CLSPN,MLF1IP,CNEP1R1,CENPA,HTATIP,CSNK1D |
| DNA Double-Strand Break Repair | TIMELESS,BARD1,RBBP8,TOPBP1,EYA2,PPP4R2,EME2,CHEK1,POLD3,EME1 |
Protein Function
TP53BP1 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding,RNA polymerase II transcription cofactor activity,damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP53BP1 itself. We selected most functions TP53BP1 had, and list some proteins which have the same functions with TP53BP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription cofactor activity | MED13A,MED15,CRSP7,MED13,MED11,RBM14,MED1,FOXH1,TDG,MED30 |
| methylated histone binding | ING2,CHD8,RAG2,MSL3,KDM4A,CBX5,FAM156A,ING3,DPPA3,PHF13 |
| telomeric DNA binding | POT1A,CTC1,NCL,TERF1,SMG6,CDAN1,TERF2,HNRNPD,OBFC1,TERFA |
| p53 binding | KDM1A,TP53,BRD4,TP63,BLM,BANP,EHMT1,EHMT2,DUSP26,STK11 |
| protein binding | MEX3C,KIF2C,MCM7,SLC4A1AP,NHLRC1,RIBC2,NOSTRIN,AXIN2,ORC3L,PPIL2 |
| RNA polymerase II activating transcription factor binding | DUSP26,SMAD3,PITX2,EP300,TBX20,NCOR1,LDB1,HEY2,BEX1,MAD2L2 |
| damaged DNA binding | APEX1,RAD52,RAD23B,CREBBP,TP63,TDG,POLB,DCLRE1A,ERCC1,OGG1 |
Interacting Protein
TP53BP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP53BP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP53BP1.
H2AFX;HIST2H4B;PAXIP1;HIST1H3D
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