TOPBP1
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Official Full Name
topoisomerase (DNA) II binding protein 1 -
Overview
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. -
Synonyms
TOPBP1;topoisomerase (DNA) II binding protein 1;DNA topoisomerase 2-binding protein 1;KIAA0259;TOP2BP1;DNA topoisomerase 2 binding protein 1;DNA topoisomerase II binding protein;DNA topoisomerase II binding protein 1;DNA topoisomerase II-beta-binding protein 1;DNA topoisomerase II-binding protein 1;DNA topoisomerase IIbeta binding protein 1;Hypothetical protein KIAA0259 [Fragment];TOPB1_HUMAN;TOPBP 1;Topoisomerase II binding protein 1
Recombinant Proteins
- Mouse
- Rhesus macaque
- Zebrafish
- Human
- Rat
- Mammalian Cells
- E.coli
- HEK293
- His
- His&T7
- His&Fc&Avi
Involved Pathway
TOPBP1 involved in several pathways and played different roles in them. We selected most pathways TOPBP1 participated on our site, such as DNA Double-Strand Break Repair,DNA Repair,HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), which may be useful for your reference. Also, other proteins which involved in the same pathway with TOPBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Double-Strand Break Repair | BABAM1,TIMELESS,GEN1,RAD9B,RHNO1,PPP4R2A,THRSP,BAZ1B,RAD1,RNF4 |
| Homologous DNA Pairing and Strand Exchange | RAD51AP1,RHNO1,WRN |
| Homology Directed Repair | FUZ,PPP4R2,WRN,TIPIN,GEN1,RNF4,PPP4R2A,PPP4CA,RAD51AP1,PPP4CB |
| HDR through Single Strand Annealing (SSA) | RHNO1,WRN |
| HDR through Homologous Recombination (HRR) | EME1,RAD9B,RAD51AP1,EME2,HUS1,WRN,RAD9,RTEL1,RHNO1,RBBP8 |
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | TIPIN,RTEL1,PPP4R2A,TP53BP1,PPP4CB,RNF168,EME2,BRCC3,BABAM1,BRE |
| DNA Repair | CLSPN,RTEL1,TDP2B,ZBTB32,TP53BP1,BAZ1B,KIAA0146,RAD17,USP43,CHEK1 |
| Presynaptic phase of homologous DNA pairing and strand exchange | RHNO1 |
Protein Function
TOPBP1 has several biochemical functions, for example, DNA binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TOPBP1 itself. We selected most functions TOPBP1 had, and list some proteins which have the same functions with TOPBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | IL12B,HCN2,UBE4A,FHL2,PLN,RABAC1,C1QL2,CNTN2,TPCN1,FUS |
| DNA binding | ACD,MAPK1,ZFP513,ZNF136,EZH2,FANCM,GCM1,NR5A1A,RMI2,HMGB3A |
Interacting Protein
TOPBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOPBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TOPBP1.
POP7;TTC31;PRICKLE3;MRPL3;RBM25;BMPR2;ERI1;Trpm7;H2afx;Atrip
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